0000000000089852
AUTHOR
Maria C. Marin
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53
10 p.-5 fig.
p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture
The adult subventricular zone (SVZ) is a highly organized microenvironment established during the first postnatal days when radial glia cells begin to transform into type B-cells and ependymal cells, all of which will form regenerative units, pinwheels, along the lateral wall of the lateral ventricle. Here, we identify p73, a p53 homologue, as a critical factor controlling both cell-type specification and structural organization of the developing mouse SVZ. We describe that p73 deficiency halts the transition of the radial glia into ependymal cells, leading to the emergence of immature cells with abnormal identities in the ventricle and resulting in loss of the ventricular integrity. p73-de…