0000000000089980

AUTHOR

Jane E. Norman

showing 3 related works from this author

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

2016

Twin pregnancies are at increased risk of stillbirth. Uncomplicated twin pregnancies are commonly delivered earlier to prevent stillbirth; however, there is a risk of neonatal complications associated with being born prior to 39 weeks’ gestation. The optimal gestational age for delivery in twin pregnancies is unknown and likely varies by chorionicity. The present study aimed to determine the prospective risk of stillbirth in women with uncomplicated monochorionic and dichorionic twin pregnancies, and neonatal mortality risks, when delivered beyond 34 weeks of gestation. Data on twin pregnancies that reported rates of stillbirth were obtained from MEDLINE, EMBASE, and Cochrane Library. Separ…

0301 basic medicinePediatricsNeonatal intensive care unitPerinatal DeathCochrane LibraryInfant Newborn Diseases0302 clinical medicineObstetrics and gynaecologyPregnancyRisk FactorsTwins DizygoticMedicineProspective StudiesProspective cohort studyreproductive and urinary physiologyTwin Pregnancyhealth care economics and organizations030219 obstetrics & reproductive medicineObstetricsIncidence (epidemiology)Absolute risk reductionObstetrics and GynecologyGestational ageProspective riskGeneral MedicineStillbirthfemale genital diseases and pregnancy complicationsMeta-analysisGestationFemalemedicine.medical_specialtyeducationGestational AgeTwin-to-twin transfusion syndrome03 medical and health sciences030225 pediatricsJournal ArticleHumansGynecologyPregnancybusiness.industryResearchInfant NewbornTwins Monozygoticmedicine.diseaseConfidence interval030104 developmental biologyIntensive Care NeonatalPregnancy TwinbusinessBMJ (Clinical research ed.)
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Effectiveness of progestogens to improve perinatal outcome in twin pregnancies : an individual participant data meta-analysis

2015

Background In twin pregnancies, the rates of adverse perinatal outcome and subsequent long-term morbidity are substantial, and mainly result from preterm birth (PTB). Objectives To assess the effectiveness of progestogen treatment in the prevention of neonatal morbidity or PTB in twin pregnancies using individual participant data meta-analysis (IPDMA). Search strategy We searched international scientific databases, trial registration websites, and references of identified articles. Selection criteria Randomised clinical trials (RCTs) of 17–hydroxyprogesterone caproate (17Pc) or vaginally administered natural progesterone, compared with placebo or no treatment. Data collection and analysis I…

Cervical pessaryAdultmedicine.medical_specialtymedicine.medical_treatmentPerinatal DeathDiseasesCervix UteriInfant Newborn DiseasesEnterocolitis NecrotizingPregnancy17 alpha-Hydroxyprogesterone CaproatemedicineHydroxyprogesteronesHumansTwin PregnancyProgesteroneBronchopulmonary DysplasiaCerebral HemorrhagePregnancyRespiratory Distress SyndromeRespiratory Distress Syndrome NewbornProgestogenIntravaginalObstetricsbusiness.industryEnterocolitisInfant NewbornObstetrics and GynecologyInfantTwinmedicine.diseaseNewbornCervical Length MeasurementClinical trialAdministration IntravaginalTreatment OutcomePremature birthCervical Length MeasurementRelative riskAdministrationPregnancy TwinPremature BirthFemaleProgestinsbusinessNecrotizing
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Progestogens to prevent preterm birth in twin pregnancies:an individual participant data meta-analysis of randomized trials

2012

Abstract Background Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death. Methods/design We propose an individual participant data meta-analysis of high quality randomized, double-blind, placebo-controlled trials of progestogen treatment in women with …

Adultmedicine.medical_specialtyReproductive medicine/dk/atira/pure/subjectarea/asjc/2700/2729lcsh:Gynecology and obstetricslaw.inventionStudy ProtocolClinical ProtocolsRandomized controlled trialPregnancylawObstetrics and GynaecologymedicineHumansAdverse effectTwin Pregnancylcsh:RG1-991Randomized Controlled Trials as TopicPregnancyModels StatisticalObstetricsbusiness.industryIndividual participant dataInfant NewbornPregnancy OutcomeObstetrics and Gynecologymedicine.diseasePregnancy ComplicationsPremature birthMeta-analysisPregnancy TwinPremature BirthFemaleProgestinsbusiness
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