0000000000094042
AUTHOR
Carmela Rosaria Arizzi
LA DOMOTICA A FAVORE DEGLI ANZIANI
RIABILITAZIONE NEUROMOTORIA NELLA M. DI PARKINSON: CONDIZIONAMENTO SENSORIALE
MALATTIA DI PARKINSON: FATTORI AMBIENTALI E GENETICI
VALUTAZIONE DELLE ALTERAZIONI COMPORTAMENTALI IN PAZIENTI CON DEMENZA DI ALZHEIMER
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
Item does not contain fulltext BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified ac…