0000000000094626
AUTHOR
Jean-michel Saliou
Characterization of rat glutathione transferases in olfactory epithelium and mucus
International audience; The olfactory epithelium is continuously exposed to exogenous chemicals, including odorants. During the past decade, the enzymes surrounding the olfactory receptors have been shown to make an important contribution to the process of olfaction. Mammalian xenobiotic metabolizing enzymes, such as cytochrome P450, esterases and glutathione transferases (GSTs), have been shown to participate in odorant clearance from the olfactory receptor environment, consequently contributing to the maintenance of sensitivity toward odorants. GSTs have previously been shown to be involved in numerous physiological processes, including detoxification, steroid hormone biosynthesis, and am…
Impact of aldehyde dehydrogenases and aldo-keto reductases on human olfactory peri-receptor events
International audience