The signature of longevity in Sicily

Ageing is a natural and physiological condition that is the result of compromised stress response, homeostatic imbalance and increased risk of developing diseases. However, if aging with good health and functions (successful ageing) and aging with disease and disability (unsuccessful ageing) depends on a combination of “positive features”, including genetic, epigenetic and phenotypic characteristics in combination with favourable environment, economic status and social involvement. In our study, we summarize some key points for the identification of a longevity signature, with a particular focus on long-living Sicilian individuals and centenarians. Analysing three different Sicilian cohorts…

Frequenza dei polimorfismi del peptide segnale del TGF-b1 in un gruppo di pazienti affetti da stenosi carotidea

Evaluation of CD1a polymorphism frequencies in patients with pancreatic cancer

The Homocysteine System

Opposite role of pro-inflammatory alleles in longevity and atherosclerosis: results of studies performed in male centenarians and male myocardial infarcion patients from Sicily

Frequency of polymorphisms of signal peptide of TGF-β1 and –1082G/A SNP at the promoter region of IL-10 gene in a group of patients with carotid stenosis.

Analysis of functionally relevant single nucleotide polymorphisms of TNF alfa and IFN gamma genes in celiac diseases

Analysis of functionally relevant single nucleotide polymorphisms of TNF alfa and of IFN gamma in celiac disease

Genetics, gender and longevity

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Analisi della frequenza del polimorfismo -330T/G della regione promoter del gene IL-2 in una coorte di centenari italiani

Search for genetic factors associated with a response to beta-interferon during relapsing-remitting multiple sclerosis