0000000000099525
AUTHOR
Julie Paradis
Short-term impact of a Western diet on the physiology of the peripheral olfactory system
Current feeding behaviors contribute to the epidemic levels of obesity and diabetes observed in Europe and worldwide. Both the quantity and the quality of ingested food are incriminated. Together with other sensory modalities, olfaction is involved in the control of food intake. Olfactory cues can influence eating behaviors, yet the nutritional status and diet can also alter olfactory abilities. Patients with metabolic disorders present impaired olfactory sensitivity which could in turn worsen their eating behaviors.Here we examined the short-term impact of a Western diet enriched in fat and sugar (High Fat High Sugar, HFHS) on the anatomy and physiology of the olfactory epithelium of postn…
Maternal Western Diet” feeding of rat dams leads to profound plasticity and GABAergic phenotype changes within reward pathway from birth to sexual maturity in the offspring
National audience
Perinatal Western Diet Consumption Leads to Profound Plasticity and GABAergic Phenotype Changes within Hypothalamus and Reward Pathway from Birth to Sexual Maturity in Rat
This article is part of the Research Topic Early Life Origins of Obesity and Type 2 Diabetes.; International audience; Perinatal maternal consumption of energy dense food increases the risk of obesity in children. This is associated with an overconsumption of palatable food that is consumed for its hedonic property. The underlying mechanism that links perinatal maternal diet and offspring preference for fat is still poorly understood. In this study, we aim at studying the influence of maternal high-fat/high-sugar diet feeding [western diet (WD)] during gestation and lactation on the reward pathways controlling feeding in the rat offspring from birth to sexual maturity. We performed a longit…
Impact of an unbalanced diet on the acquisition of food preferences and the development of reward circuits in rat
International audience
Consuming a balanced diet from weaning reverses the programming of food preferences in offspring of Western-Diet-fed rat dams
National audience