0000000000103790
AUTHOR
Tomasello G
CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS
Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, fe…
Arthritis Associated with Ulcerative Colitis: Our Experience in Palermo
To The Editor: Ulcerative colitis (UC) is one of the inflammatory bowel diseases, which affects the small intestine and colon [1]. The pathophysiology of UC is not known [2, 3]. The association between arthritis and UC is well known. The authors report the frequency of arthritis in 53 Sicilian patients with UC. The diagnosis of UC was made according to criteria described by Schachter and Kirsner [4]. The involvement of sacroilitic joints was assessed radiologically according to Bennett and Burch grade (0=normal joint, 1=suspicious sacroiliitis 2=abnormal joint with sclerosis and/or erosions, 3=unequivocally abnormal with erosions, sclerosis, widening or narrowing or partly ankylosed, 4=tota…
Choroidal metastasis from lung adenocarcinoma: a rare case report.
The choroid is the most common site for intraocular metastatic di sease. Orbital metastasis as metastatic site of lung adenocarcinoma is very rare and in literature a very exiguous number of cases is present. This is a case report of a woman with history of lung adenocarcinoma and, after surgery, detection of a choroidal mass described as lung metastasis, responding to Gefinitib therapy. However a biopsy was not performed. After two years there was a great dimension decrement of the lung metastasis but she is still suffering from recurrent pleural effusion, with pleural thickenings biopsied and diagnosed as recurrences of disease.
COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASES: EFFECTS ON DIET AND ANTIOXIDANTS
It is well established that oxidative stress is common in inflammatory bowel diseases (IBDs). Accordingly, antioxidants are recommended for treatment. The aim of this study is to compare the effects of antioxidants contained in the various types of tea on symptoms and evolution of IBD and colorectal cancer (CRC). Analysis of the literature revealed that the theaflavin-3, 30-digallate (TFDG) contained in black tea, and epigallocatechin-3-O-gallate (EGCG) contained in green tea have protective effects against oxidative stress. Moreover, these substances are involved in many biochemical processes responsible for inflammation and proliferation of cancer cells. It is documented that both TFDG an…
THE USE OF ARGENTUM-QUARTZ SOLUTION IN PRIMARY OR RECURRENT PERIANAL FISTULAS: FIRST EXPERIENCE ON THREE CASES
Primary perianal fistulous pathology represents a painful condition often noticeable in patients affected by Crohn's disease or Ulcerative colitis. It causes difficult defecation and can evolve in perianal abscess that should be urgently ascertained and drained. The present work aims to propose Argentum-Quartz® as valid non-surgical therapeutic treatment in order to reach a more comfortable perianal fistula healing. In fact, our preliminary data allow us to consider Argentum Quartz® ideally employable for treatment of perianal fistulas associated or not with IBDs, representing a reliable sphincter-sparing solution.
Intestinal dysbiosis and hormonal neuroendocrine secretion in the fibromyalgic patient
Fibromyalgia is a rheumatic syndrome and its pathogenesis is controversial. The recent literature has placed considerable attention on the link between alteration of the intestinal microbiota and fibromyalgia, emphasizing the close connection between the neuroenteric system and the CNS. This study aims to evaluate the probable relationship between intestinal dysbiosis and altered secretion of hormones and vitamins such as cortisol, serotonin, Vitamin D and thyroid hormones in a patient with fibromyalgia.
Orthopaedic experience on inflammatory bowel disease (Lesniowski-Crohn's disease and ulcerative colitis)
Inflammatory Bowel Diseasae (IBD)is a group of inflammatory conditions of the gastrointestinal tract. The major types of IBD are Lesniowski-Crohn's disease (L-CD) and ulcerative colitis (UC). IBD sometimes presents with arthritic manifestations. The peripheral arthitis is a problem for the orthopaedist and the physiatrist. The Authors retrospectively reviewed 65 sicilian patients with IBD (38 with UC, 27 with L-CD) over a period of 5 years. All patients underwent clinical examinations, laboratory and imaging studies, and were screened for the presence of the rheumatoid factor. All patients also attended eight to ten 50-minutes sessions of physioterapy over a six-week period. REsults: 38 pat…
A 30 YEAR EXPERIENCE IN THE MANAGEMENT OF ANAL FISTULA
Anal fistula has been recognized for centuries, and yet, its treatment remains a challenge for surgeons till today. in this study, a 30 year experience of treating anal fistula is being reported and discussed in light of the various recognized management methods. A total of 320 patients were treated by fistulotomy, fistilectomy, fistula plugging, or seton technique. Data showed that fistula plugging carried the highest failure rate (89%) seconded by fistulectomy (37%), seton procedure (24,5%) and fistulotomy (15,6%). High transphincteric fistulas were more likely to predict failure compared to low transphinteric; intersphinteric and subcutaneous fistulas (37,5% versus 9,5 %, 7,3% and 0% res…
DYSMICROBISM, INFLAMMATORY BOWEL DISEASE AND THYROIDITIS: ANALYSIS OF THE LITERATURE
The human body is colonized by a large number of microbes that are collectively referred to as the microbiota. They interact with the hosting organism and some do contribute to the physiological maintenance of the general good health thru regulation of some metabolic processes while some others are essential for the synthesis of vitamins and short-chain fatty acids. The abnormal variation, in the quality and/or quantity of individual bacterial species residing in the gastro-intestinal tract, is called dysmicrobism. The immune system of the host will respond to these changes at the intestinal mucosa level which could lead to Inflammatory Bowel Diseases (IBD). This inflammatory immune respo…
A BRIEF DISSECTION GUIDE TO HUMAN THORAX
The purpose of this technical report is to present that, in summer 2018, a group of students from the University of Palermo did at the University of malta. The students have the experience to dissected a thorax under a guide to expert dissectors. This work would be also a small dissection guide for young students who want to learn the main bases of dissection
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in immunomodulation and tumor progression. Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the expression levels of Hsp10 and Hsp90 in normal mucosa and adenocarcinoma samples of human large bowel.Samples of normal mucosa and adenocarcinoma were collected and Reverse transcriptase-polymerase chain reaction RT-PCR, western blotting (WB) analyses, as well as immunohistochemistry were performed to evaluate the expression levels of Hsp10 and Hsp90…
THE SAXOPHONIST'S HERNIA: A RARE CASEREPORT OF ANTERIOR PRIMARY PERINEAL HERNIA IN A YOUNG MALE PATIENT.
Perineal hernia is the protrusion of an intra-abdominal structure into the perineal area, that could be primitive or secondary to trauma or abdominoperineal resection. Main treatment could be transabdominal, transperineal or combined. Here is a rare case of anterior perineal hernia in a young saxophone male patient, treated with a mininvasive perineal approach. A 25-year-old Caucasian male patient referred 1-year history of perineal pain. The pain was more severe when he played his saxophone. Local exam was negative but a dynamic perineal ultrasonography revealed a small anterior perineal hernia. The defect was repaired with a polypropylene plug and the patient was discharged the day after.…