0000000000108616

AUTHOR

Leonardo Bruno

showing 7 related works from this author

DRIVER BEHAVIOUR AT URBAN INTERSECTIONS

2005

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ELABORAZIONE DELLE IMMAGINI DIGITALI. STUDIO DELLE CONDIZIONI OPERATIVE DELLE INTERSEZIONI STRADALI URBANE

2006

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IMAGE PROCESSING FOR ROAD SIGNS INVENTORY

2007

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METHODOLOGICAL APPROACH TO FRICTION ASSESSMENT. USE OF A WELL-EQUIPPED CAR.

2004

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IL RITARDO ALLE INTERSEZIONI SEMAFORIZZATE. UN APPROCCIO PROBABILISTICO

2006

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What are the Cancer Risks in BRCA Carriers Apart from Those Regarding the Breast and the Ovary?

2012

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to familial breast and/or ovarian cancer. The lifetime risk of members of families with genetic predisposition depends on the mutations of susceptibility genes. BRCA1 mutations seem to confer the highest risk of developing neoplastic diseases. Apart from breast and ovarian cancer mutations in BRCA, related pathways are supposed to confer a smaller risk for additional cancers (colon, melanoma, pancreas, lymphoma, prostate, liver). All these tumors have an inherited component not necessarily associated with genetic susceptibility to BRCA genes. To date he main focus of this review has been argued still with difficulty…

Oncologymedicine.medical_specialtybusiness.industrySettore MED/06 - Oncologia MedicaObstetrics and GynecologyCancerOvarymedicine.diseasemedicine.anatomical_structureInternal medicinemedicineCancer riskbusinessBRCA genes BRCA mutations cancer risk.Brca genes
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How Much of Familial Breast Cancer Risk is Currently Explained by the Known Genes?

2012

The need to answer the question “how much of the familial risk is currently explained by the known genes?” has increased ,and although BRCA1 and BRCA2 are considered the two major breast cancer (BC) susceptibility genes, they do not justify the entire percentage of all hereditary BC cases. The current consensus is that other BC predisposing genes could explain at least a portion of the remaining non-mutated familial cases, including not only other high- penetrance BC genes, but also moderate and low-penetrance genes. Considering these three different categories of genes, a gap of risk estimation in breast cancer can be observed. Moreover, different researchers tried to give significance to …

OncologyBreast cancer high-penetrance genes low-moderate penetrance genes.medicine.medical_specialtybusiness.industryInternal medicineObstetrics and GynecologyMedicineFamilial breast cancerbusinessGeneCurrent Women's Health Reviews
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