0000000000112957
AUTHOR
Stéphanie Veloso Da Silva
Olfactory xenobiotic metabolizing enzymes have an impact on the stimulating properties of some odorants
International audience
Biotransformation of odorants modifies the olfactory signal
International audience
Odorant metabolism catalyzed by olfactory mucosal enzymes influences peripheral olfactory responses in rats.
International audience; A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450 monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian olfactory mucosa (OM). These enzymes are known to catalyze the biotransformation of exogenous compounds to facilitate elimination. However, the functions of these enzymes in the olfactory epithelium are not clearly understood. In addition to protecting against inhaled toxic compounds, these enzymes could also metabolize odorant molecules, and thus modify their stimulating properties or inactivate them. In the present study, we investigated the in vitro biotransformation of odorant molecules in the rat …