Diorganotin(IV) and triorganotin(IV) complexes of meso-tetra(4-sulfonatophenyl) porphine induce apoptosis in A375 human melanoma cells

The cytotoxic effect of several diorganotin(IV) and triorganotin(IV)-meso-tetra(4-sulfonatophenyl)porphine derivatives was tested and only the (Bu(2)Sn)(2)TPPS and the (Bu(3)Sn)(4)TPPS showed cytotoxicity on A375 human melanoma cells. To examine the pathway of (Bu(2)Sn)(2)TPPS or (Bu(3)Sn)(4)TPPS induced A375 cell death, DNA fragmentation analysis, Annexin V binding and PI uptake as well as caspases activation analysis by Western blot were carried out. A375 cells treated exhibited several typical characteristics of apoptosis. Both the (Bu(2)Sn)(2)TPPS and the (Bu(3)Sn)(4)TPPS compounds activate caspase-8 and caspase-9 leading to caspase-3 activation. Thus, we propose that these two porphiri…

TPPS derivatives induce apoptosis on A375 human melanoma cells

Ciclo riproduttivo di Arbacia lixula (Linneo, 1758) (Echinodermata: echinoidea) nella AMP “Isola di Ustica”

Abnormal Expression of the major Histocompatibility Complex Class II (MHC Class II) Molecules in melanoma and cytotoxic effect of meso-tetra-(4-sulfonatophenyl)porphynate (=TPPS) derivatives.