0000000000116453

AUTHOR

D. Cocito

showing 4 related works from this author

Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria?

2021

Background and purpose The aim was to identify the clinical and diagnostic investigations that may help to support a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients not fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS) electrodiagnostic criteria. Methods The data from patients with a clinical diagnosis of CIDP included in a national database were retrospectively reviewed. Results In all, 535 patients with a diagnosis of CIDP were included. This diagnosis fulfilled the EFNS/PNS criteria in 468 patients (87.2%) (definite in 430, probable in 33, possible in three, while two had chronic immune sensory p…

Pediatricsmedicine.medical_specialtyResponse to therapyDatabases FactualNeural ConductionSettore MED/2603 medical and health sciences0302 clinical medicinePeripheral nerveRetrospective StudieMedicineHumansMedical historyIn patient030212 general & internal medicinePeripheral NervesRetrospective Studieschronic inflammatory demyelinating polyradiculoneuropathybusiness.industryPolyradiculoneuropathyPolyradiculopathymedicine.diseaseelectrophysiologySettore MED/26 - NEUROLOGIANeurologyPolyradiculoneuropathy Chronic Inflammatory DemyelinatingClinical diagnosisPeripheral Nervediagnostic criteriaNational databaseNeurology (clinical)chronic inflammatory demyelinating polyradiculoneuropathy; diagnostic criteria; electrophysiologybusiness030217 neurology & neurosurgeryHuman
researchProduct

Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A Retrospective, Multicenter, RealWorld Study

2022

Introduction: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Most real-world research on BRV has focused on refractory epilepsy. The aim of this analysis was to assess the 12-month effectiveness and tolerability of adjunctive BRV when used as early or late adjunctive treatment in patients included in the BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST). Methods: BRIVAFIRST was a 12-month retrospective, multicenter study including adult patients prescribed adjunctive BRV. Effectiveness outcomes included the rates of sustained seizure response, sustained seizure freedom, and treatment discontinua…

Antiseizure medicationFocal seizuresAntiseizure medication; Brivaracetam; Epilepsy; Focal seizures.Antiseizure medication; Brivaracetam; Epilepsy; Focal seizures;EpilepsyNeurologyBrivaracetamSettore MED/26 - NeurologiaNeurology (clinical)Antiseizure medication; Brivaracetam; Epilepsy; Focal seizuresSettore MED/26Settore MED/39 - Neuropsichiatria Infantile
researchProduct

Relevance of diagnostic investigations in chronic inflammatory demyelinating poliradiculoneuropathy: Data from the Italian CIDP database

2020

The objective of our work was to report the clinical features and the relevance of diagnostic investigations in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We retrospectively reviewed data from patients with a clinical diagnosis of CIDP included in a national database. Among the 500 included patients with a clinical diagnosis of CIDP, 437 patients (87%) fulfilled the European Federation of Neurological Societies and Peripheral Nerve Society criteria for CIDP (definite in 407, probable in 26, possible in four). In 352 patients (86%) motor nerve conduction abnormalities consistent with demyelination were sufficient for the diagnosis of definite CIDP. In 55 …

medicine.medical_specialtyperipheral neuropathyResponse to therapyMotor nerveCIDPSettore MED/26chronic inflammatory demyelinating neuropathy; CIDP; diagnostic criteria; EMG; peripheral neuropathy03 medical and health sciences0302 clinical medicineEMGInternal medicinemedicineIn patientNerve biopsymedicine.diagnostic_testbusiness.industryGeneral Neurosciencechronic inflammatory demyelinating neuropathyPolyradiculoneuropathymedicine.diseaseCIDP; Chronic inflammatory demyelinating neuropathy; Diagnostic criteria; EMG; Peripheral neuropathyPeripheral neuropathymedicine.anatomical_structure030220 oncology & carcinogenesisClinical diagnosisdiagnostic criteriaNeurology (clinical)business030217 neurology & neurosurgerySensory nerve
researchProduct

Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)

2021

Background: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic setting are a useful complement to characterize the drug profile. Objective: This multicentre study assessed the effectiveness and tolerability of adjunctive BRV in a large population of patients with focal epilepsy in the context of real-world clinical practice. Methods: The BRIVAFIRST (BRIVAracetam add-on First Italian netwoRk STudy) was a retrospective, multicentre study including adult patients prescribed adjunctive BRV. Patients with focal epilepsy and 12-month follow-up were considered. Main outcomes includ…

medicine.medical_specialtybusiness.industryContext (language use)Brivaracetammedicine.diseaseDiscontinuationlaw.inventionPsychiatry and Mental healthEpilepsyRandomized controlled trialTolerabilityfocal epilepsy add-on therapy seizurelawConcomitantInternal medicineMedicinePharmacology (medical)Neurology (clinical)LevetiracetamOriginal Research Articlebusinessmedicine.drug
researchProduct