0000000000119486

AUTHOR

E. Santucci

showing 2 related works from this author

Potential dopamine prodrug-loaded liposomes: preparation, characterization and in vitro stability studies

2009

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoLiposomes Dopamine pro-drugs
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Potential dopamine prodrug-loaded liposomes: preparation, characterization, andin vitrostability studies

2010

Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential pro- drugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bio-availability of the dopamine prodrug, 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DOPH), it was encapsulated in unilamellar liposomes of dimiristoylphosphatidylcholine (DMPC)and cholesterol. Vesicles were characterized by dynamic light scattering in order to evaluate their dimensions and vesicle stability, by zeta-potential measurements, by means of electronic mi…

LightDopaminePhenylalanineenzymatic stabilityPharmaceutical Sciencechemical stability; dopamine prodrug; enzymatic stability; liposomeschemical stabilityDrug StabilityDynamic light scatteringDopamineZeta potentialmedicineHumansScattering RadiationProdrugsLiposomeChromatographyCalorimetry Differential ScanningChemistryVesicleProdrugSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPermeability (electromagnetism)LiposomesliposomeBiophysicsChemical stabilityDimyristoylphosphatidylcholineDopamine prodrugmedicine.drugJournal of Liposome Research
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