A new approach for an adaptive forest management planning to improve resilience of beech forests in relation to climate change: the LIFE AForClimate project

Predictive factors of response to mTOR inhibitors in neuroendocrine tumours

Medical treatment of neuroendocrine tumours (NETs) has drawn a lot of attention due to the recent demonstration of efficacy of several drugs on progression-free survival, including somatostatin analogs, small tyrosine kinase inhibitors and mTOR inhibitors (or rapalogs). The latter are approved as therapeutic agents in advanced pancreatic NETs and have been demonstrated to be effective in different types of NETs, with variable efficacy due to the development of resistance to treatment. Early detection of patients that may benefit from rapalogs treatment is of paramount importance in order to select the better treatment and avoid ineffective and expensive treatments. Predictive markers for th…

Climate variability in forest management planning: The LIFE AForClimate project.

Previous research experiences have shown that climate variability can play a relevant role in forest planning and management within a climate change scenario. In forest planning and management, yield tables, site quality indices, age classes, and rates of growth are some of the most frequently used parameters and tools. However, these ‘traditional’ methods do not include the influence of climate variability on forest growth over time, although it is one of the main influencing factors in tree growth. Changes in climate determine changes in thermo-pluviometric regimes that often have a marked influence on forest growth trends. Forest biomass, resilience, and carbon sequestration may be damag…