Polymorphonuclear leukocyte membrane fluidity and cytosolic Ca2+ content at baseline and after activation in essential hypertension

Polymorphonuclear leukocyte integrins in chronic renal failure

Patients with chronic renal failure (CRF), in comparison with general population, show a higher cardiovascular mortality, not fully explained by the "traditional" risk factors. Among the new factors that have been hypothesized, leukocytes might play an important role. In a group of patients with mild CRF we determined, at baseline and after in vitro activation with 4-phorbol-12-myristate-13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP), the polymorphonuclear leukocytes (PMN) beta2-integrin pattern (CD11a, CD11b, CD11c and CD18) by using indirect immunofluorescence with a flow cytometer. At baseline we observed an increase in the phenotypical expression of CD11b, CD11c and…

Polymorphonuclear leukocyte cytosolic Ca2+ content in non-dialyzed subjects with chronic renal failure

Leukocyte activation markers and oxidative status in chronic kidney disease

Lipid peroxidation and total antioxidant status in juvenile myocardial infarction.

In a group of young subjects with acute myocardial infarction (AMI) (97 men and 8 women; mean age 39.6+/-5.5 years) we examined the thiobarbituric acid - reactive substances and the total antioxidant status at the initial stage and after 12 months. The same parameters were examined in a group of 55 control subjects. Our results show that, while in control subjects there was a negative correlation (p<0.001) between these two parameters, no correlation was found in juvenile myocardial infarction at the initial stage as well as after 12 months.