0000000000122917

AUTHOR

Nir Barzilai

showing 4 related works from this author

Interventions to Slow Aging in Humans: Are We Ready?

2015

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consens…

GerontologyAgingDisease onsetPrescription DrugsLongevityPsychological interventionReviewsBiologyAMP-Activated Protein KinasesGrowth hormoneAging; Anti-aging; Centenarians; Dietary restriction; Lifespan studies; Longevity gene; Longevity regulation; Cell Biology; AgingDietary interventionsBiological FactorsMicelongevity geneSettore BIO/13 - Biologia ApplicataAnimalsHumansSirtuinsProtein restrictionCentenarianInsulin-Like Growth Factor ILifespan studieCaloric RestrictionSettore MED/04 - Patologia GeneraleGeroscienceGene targetsRibosomal Protein S6 KinasesTOR Serine-Threonine Kinasesanti-agingdietary restrictionCell Biologydietary restriction ; lifespan studies ; longevity gene ; centenarians ; anti-aging ; longevity regulation ; aginglongevity regulation3. Good healthDietEnzyme ActivationGene Expression RegulationGrowth HormoneGenetics of agingcentenariansaging; anti-aging; centenarians; dietary restriction; lifespan studies; longevity gene; longevity regulationSignal Transductionlifespan studies
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Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement

2018

In May 2012, a group of scientists and clinicians met in Athens (Greece) to consider the relevance of ageing, longevity, exceptional longevity and related genetic and non genetic markers. During this meeting, we firstly reviewed recent epidemiological and clinical studies on ageing, longevity and exceptional longevity, briefly analysed the ageing theories and discussed successful and unsuccessful ageing also taking into account the evolutionary perspective. Secondly, we considered the three phenotypes based on the definition of ageing, longevity and exceptional longevity and the associated biomarkers. Third, we discussed proposed treatments suitable to counteract or slow down ageing. Finall…

Genetic MarkersGerontologyAgingStatement (logic)media_common.quotation_subjectLongevityMESH: Genetic MarkersBiologyMESH: Phenotype[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemGenetic MarkerAnimalsHumansMESH: AgingMESH: AnimalsComputingMilieux_MISCELLANEOUSmedia_commonPharmacologyMESH: HumansAnimalLongevityCongresses as TopicPhenotypeAgeing Longevity Age-related diseasesMESH: LongevityAgeingBiological MarkerMESH: BiomarkersCardiology and Cardiovascular MedicineMESH: Congresses as TopicBiomarkersHuman
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The Challenges in Moving from Ageing to Successful Longevity

2014

During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population. Human life span is mainly dependent on environmental and genetic factors. Favourable modifications of lifestyle factors (e.g. physical activity, diet and not smoking) and healthcare (e.g. effective vascular disease prevention) have also increased human life span. Genetic factors contribute to the variation of human life span by around 25%, which is believed to be more profound after 85 years of age. It is likely that multiple factors influence life span and we need answers to questions such as: 1) What does it take to reach 100?, 2) Do centenarians have better he…

ageing longevity age-related diseasesGerontologyAgingYounger ageHormone Replacement Therapymedia_common.quotation_subjectLongevityPopulationHealth careAnimalsHumansMedicineeducationLife Stylemedia_commonSettore MED/04 - Patologia GeneraleAged 80 and overPharmacologyeducation.field_of_studyAnimalbusiness.industryLongevityCognitionDietNutrigenomicsAgeingLife expectancyCardiology and Cardiovascular MedicinebusinessHumanCurrent Vascular Pharmacology
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Aging and chronic inflammation: highlights from a multidisciplinary workshop

2023

Abstract: Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evide…

Settore MED/04 - Patologia GeneraleAgingBiomodulina TImmunosenescenceCell senescenceSenolyticHuman medicineChronic inflammationSASPBiologyInflammagingMetformin
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