0000000000123207
AUTHOR
Tobias Albrecht
DS_DISC859837 – Supplemental material for Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2
Supplemental material, DS_DISC859837 for Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2 by Beatrice Snieder, Sabine Brast, Alexander Grabner, Sven Buchholz, Rita Schröter, Gilles A. Spoden, Luise Florin, Johanna Salomon, Tobias Albrecht, Vivien Barz, Alex Sparreboom and Giuliano Ciarimboli in SLAS Discovery
Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2
Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2), suggesting a possible role in modulating neurotransmitter activity in the liver, kidney, and brain, and their clearance from the blood. Even though there are several data demonstrating that OCTs are regulated under various patho-physiological conditions, it remains largely unknown which proteins directly interact with OCTs and thereby influence …