Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans
Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin®
Synthesis, structure, properties and antimicrobial activity of para trifluoromethyl phenylboronic derivatives
The [2-formyl-4-(trifluoromethyl)phenyl]boronic acid as well as its benzoxaborole and bis(benzoxaborole) derivatives were obtained and their properties studied. The 2-formyl compound displays an unusual structure in the crystalline state, with a significant twist of the boronic group, whereas in DMSO solution it tautomerizes with formation of a cyclic isomer. All the studied compounds exhibit relatively high acidity as well as a reasonable antimicrobial activity. Docking studies showed interactions of all the investigated compounds with the binding pocket of Candida albicans LeuRS. High activity against Bacillus cereus was determined for the 2-formyl compound as well as for the novel bis(be…
Novel 2,6-disubstituted phenylboronic compounds - Synthesis, crystal structures, solution behaviour and reactivity
Abstract 2,6-Diformylphenylboronic acid has been synthesized and characterized both in the solid state as well as in solution. In crystal, an unusual structural pattern has been found with the formation of intermolecular hydrogen bonds by B(OH) 2 and CHO groups as well as water molecules. In solution tautomeric equilibrium with the formation of oxaborole ring by one of the formyl groups was proved on the basis of multinuclear NMR spectroscopy. The title compound reacts with secondary mono- and diamines to form various types of substituted benzoxaboroles, which have been characterized by XRD and spectroscopic methods.
(Trifluoromethoxy)Phenylboronic Acids: Structures, Properties, and Antibacterial Activity.
Three isomers of (trifluoromethoxy)phenylboronic acids were studied in the context of their physicochemical, structural, antimicrobial and spectroscopic properties. They were characterized by 1H, 13C, 11B and 19F NMR spectroscopy. The acidity of all the isomers was evaluated by both spectrophotometric and potentiometric titrations. The introduction of the -OCF3 group influences the acidity, depending, however, on the position of a substituent, with the ortho isomer being the least acidic. Molecular and crystal structures of ortho and para isomers were determined by the single crystal XRD method. Hydrogen bonded dimers are the basic structural motives of the investigated molecules in the sol…
Synthesis, Properties and Antimicrobial Activity of 5-Trifluoromethyl-2-formylphenylboronic Acid
2-Formylphenylboronic acids display many interesting features, not only from synthetic but also from an application as well as structural points of view. 5-Trifluoromethyl-2-formyl phenylboronic acid has been synthesized and characterized in terms of its structure and properties. The presence of an electron-withdrawing substituent results in a considerable rise in the acidity in comparison with its analogues. In some solutions, the title compound isomerizes with formation of the corresponding 3-hydroxybenzoxaborole. Taking into account the probable mechanism of antifungal action of benzoxaboroles, which blocks the cytoplasmic leucyl-tRNA synthetase (LeuRS) of the microorganism, docking stud…
CCDC 1998837: Experimental Crystal Structure Determination
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CCDC 2082738: Experimental Crystal Structure Determination
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CCDC 1029677: Experimental Crystal Structure Determination
Related Article: Agnieszka Adamczyk-Woźniak, Krzysztof Ejsmont, Błażej Gierczyk, Ewa Kaczorowska, Alicja Matuszewska, Grzegorz Schroeder, Andrzej Sporzyński, Bartosz Zarychta|2015|J.Organomet.Chem.|788|36|doi:10.1016/j.jorganchem.2015.04.026
CCDC 1959978: Experimental Crystal Structure Determination
Related Article: Agnieszka Adamczyk-Woźniak, Jan T. Gozdalik, Dorota Wieczorek, Izabela D. Madura, Ewa Kaczorowska, Ewa Brzezińska, Andrzej Sporzyński, Jacek Lipok|2020|Molecules|25|799|doi:10.3390/molecules25040799
CCDC 1029678: Experimental Crystal Structure Determination
Related Article: Agnieszka Adamczyk-Woźniak, Krzysztof Ejsmont, Błażej Gierczyk, Ewa Kaczorowska, Alicja Matuszewska, Grzegorz Schroeder, Andrzej Sporzyński, Bartosz Zarychta|2015|J.Organomet.Chem.|788|36|doi:10.1016/j.jorganchem.2015.04.026
CCDC 1998838: Experimental Crystal Structure Determination
Related Article: Dorota Wieczorek, Ewa Kaczorowska, Marta Wiśniewska, Izabela D. Madura, Magdalena Leśniak, Jacek Lipok, Agnieszka Adamczyk-Woźniak|2020|Molecules|25|5999|doi:10.3390/molecules25245999