0000000000129324
AUTHOR
Wei Shi
showing 7 related works from this author
A comparative study on the dynamic response of three semisubmersible floating offshore wind turbines
2019
Abstract Currently, there is a great interest to globally develop offshore wind energy due to the greenhouse effect and energy crisis. Great efforts have been devoted to develop reliable floating offshore wind energy technology to exploit the wind energy resources in deep seas. This paper presents a comparative study of the dynamic response of three different semisubmersible floating wind turbine structures. All the three platforms support the same 5MW wind turbine. The platforms examined are: a V-shaped Semi, an OC4-DeepCwind Semi and a Braceless Semi at 200 m water depth. A dynamic analysis is carried out in order to calculate and compare the performance of these platforms. The comparison…
Optimising experimental research in respiratory diseases: an ERS statement
2018
Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective.The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numb…
Eighteen-Year Farming Management Moderately Shapes the Soil Microbial Community Structure but Promotes Habitat-Specific Taxa
2018
Soil microbes have critical influence on the productivity and sustainability of agricultural ecosystems, yet the magnitude and direction to which management practices affect the soil microbial community remain unclear. This work aimed to examine the impacts of three farming systems, conventional grain cropping (CON), organic grain cropping (ORG), and grain cropping-pasture rotation (ICL), on the soil microbial community structure and putative gene abundances of N transformations using high-throughput 16S rRNA gene and ITS sequencing approaches. Two additional systems, a forest plantation (PF) and an abandoned agricultural field subject to natural succession (SUC), were also included for bet…
Methylation Reprogramming and Chromosomal Aneuploidy in In Vivo Fertilized and Cloned Rabbit Preimplantation Embryos1
2004
Active demethylation of the paternal genome but not of the maternal genome occurs in fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation wave is important for embryonic development, we have analyzed the global methylation patterns of both in vivo-fertilized and cloned rabbit embryos. Anti-5-methylcytosine immunofluorescence of in vivo-fertilized rabbit embryos revealed that the equally high methylation levels of the paternal and maternal genomes are largely maintained from the zygote up to the 16-cell stage. The lack of detectable methylation changes in rabbit preimplantation embryos suggests that genome-wide demethylation is not an obligatory requireme…
Effect of a Passive Tuned Mass Damper on Offshore Installation of a Wind Turbine Nacelle
2021
Abstract Although the installation of offshore wind turbines takes place in calm seas, successful mating of wind turbine components can be challenging due to the relative motions between the two mating parts. This work investigates the effect of a passive tuned mass damper on the mating processes of a nacelle for a 10-megawatt (MW) offshore wind turbine. A nacelle with lifting wires and a monopile with a mass damper are respectively modelled using the multibody formulation in the HAWC2 program. A single mass damper is tuned to target at the first natural period of the monopile and is coupled to the main program using a dynamic link library. Afterwards, numerical simulations were carried out…
Second-order hydrodynamic effects on the response of three semisubmersible floating offshore wind turbines
2020
Abstract Floating structures have become the most feasible solution for supporting wind turbines when offshore wind project move to deeper water. In this paper, a hydrodynamic analysis of three different semisubmersible floating offshore wind turbines is carried out including second-order hydrodynamic effects. The three examined platforms are V-shaped semisubmersible, Braceless semisubmersible and OC4-DeepCwind semisubmersible and are used to support the NREL 5 MW reference wind turbine. The main objective of the present study is to investigate and compare the hydrodynamic response of the three different semisubmersible floaters in two water depths (100 m, and 200 m) under different load co…
A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets.
2018
International audience; NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we describe a spontaneous point mutation of cysteine to arginine (C14R) in the signal peptide of the NKp46 protein in congenic Ly5.1 mice and the newly generated NCR(B6C14R) strain. Ly5.1(C14R) NK cells expressed similar levels of Ncr1 mRNA as C57BL/6, but showed impaired surface NKp46 and reduced ability to control melanoma tumors in vivo. Expression of the mutant NKp46(C14R) in 293T cells showed that NKp46 protein trafficking to the cell surface …