MEX3A as a post-transcriptional regulator of neurogenesis in the adult brain

2019

Tissue-resident adult stem cells (SCs) constitute a unique pool of undifferentiated cells responsible for tissue maintenance and potential regeneration after injury. All somatic SCs are defined by their ability to produce differentiated progeny (developmental potential) while preserving the capacity to self-replicate (self-renewal). In many adult tissues, SCs co-exist in several states of activation, being the quiescent reversible cell cycle-arrested state responsible for the long-term maintenance of the SC pool. Cell state transitions in these populations, such as activation and differentiation, must be tightly regulated to maintain homeostatic balance. Such state changes are dynamic and r…