Author: Gabriel Lopez-berestein

0000000000133449

AUTHOR

Gabriel Lopez-berestein

Apoptotic induction in transformed follicular lymphoma cells by Bcl-2 downregulation.

The roles of Bcl-2 protein and the protein ratio of Bcl-2/Bax in regulating cell growth in various lymphoma cell lines were examined. A dose-dependent decrease in Bcl-2 protein expression was observed in the different lymphomas incubated with lipid-incorporated bcl-2 antisense oligonucleotides (L-bcl-2). Growth inhibition was observed in a transformed follicular lymphoma (FL) cell line, which has the t(14;18) translocation and Bcl-2 protein overexpression. One of the mechanisms by which L-bcl-2 growth inhibition is mediated in these transformed FL cells might be through apoptotic induction, because the treated cells had an increased apoptotic index and showed the typical DNA fragmentation. …

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Autophagy

Klionsky, Daniel J. et al.

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PEPhysical Sciences and Engineering
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