0000000000133759

AUTHOR

B. De Unamuno-bustos

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Systematic review of BRAF/MEK inhibitors‐induced Severe Cutaneous Adverse Reactions (SCARs)

2020

Severe cutaneous adverse reactions (SCARs) [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed eruption (GBFE)] are severe drug reactions that often require hospitalization and could be fatal. BRAF and MEK inhibitors (BRAF/MEKi) are a standard of care in patients with BRAF-mutated metastatic melanomas. These agents are administered until disease progression or unacceptable toxicity occurs. This review has focus on BRAF/MEKi-induced SCARs. A systematic search of the following terms: 'vemurafenib', 'cobimetinib', 'dabrafenib', 'trametinib',…

Proto-Oncogene Proteins B-rafmedicine.medical_specialtyDermatologyCicatrix030207 dermatology & venereal diseases03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicineHumansVemurafenibRetrospective StudiesMitogen-Activated Protein Kinase KinasesTrametinibCobimetinibbusiness.industryBinimetinibDabrafenibAcute generalized exanthematous pustulosismedicine.diseaseDermatologyToxic epidermal necrolysisInfectious DiseasesAcute Generalized Exanthematous PustulosischemistryDrug Hypersensitivity SyndromeStevens-Johnson Syndrome030220 oncology & carcinogenesisbusinessmedicine.drugJournal of the European Academy of Dermatology and Venereology
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