0000000000135162

AUTHOR

R De La Cámara

showing 4 related works from this author

Surveillance for adenovirus DNAemia early after transplantation in adult recipients of unrelated-donor allogeneic stem cell transplants in the absenc…

2011

Surveillance for adenovirus DNAemia early after transplantation in adult recipients of unrelated-donor allogeneic stem cell transplants in the absence of clinically suspected infection

MaleTransplantationbusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesHematologyPolymerase Chain ReactionAdenoviridaeAdenovirus Infections HumanTransplantationsurgical procedures operativeUnrelated DonorImmunologyHumansMedicineFemaleStem cellbusinessBone Marrow Transplantation
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Reconstitution of CMV pp65 and IE-1-specific IFN-γ CD8+ and CD4+ T-cell responses affording protection from CMV DNAemia following allogeneic hematopo…

2011

Threshold levels of CMV-specific T-cell populations presumably affording protection from active CMV infection in allo-SCT recipients have been proposed, but lack extensive validation. We quantified CMV pp65 and immediate-early 1-specific IFN-γ CD8(+) and CD4(+) T cell responses at days +30, +60 and +90 after transplantation in 133 patients, and established cutoff cell levels protecting from CMV DNAemia within the first 120 days after transplantation. No patients showing IFN-γ CD8(+) or IFN-γ CD4(+) T-cell counts1.0 and1.2 cells/μL, respectively, developed a subsequent episode of CMV DNAemia. Initial or recurrent episodes of CMV DNAemia occurred in the face of IFN-γ T-cell levels below defin…

AdultCD4-Positive T-LymphocytesMaleAdolescentGlobulinT cellCytomegalovirusCD8-Positive T-LymphocytesImmediate-Early ProteinsViral Matrix ProteinsInterferon-gammamedicineHumansTransplantation HomologousAgedTransplantationCd4 t cellbiologyUmbilical Cord Blood Transplantationbusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesHematologyCmv dnaemiaMiddle AgedPhosphoproteinsTransplantationHaematopoiesismedicine.anatomical_structureCytomegalovirus InfectionsDNA ViralImmunologybiology.proteinFemaleVirus ActivationbusinessCD8Bone Marrow Transplantation
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Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia an…

2009

Rising levels of cytomegalovirus (CMV) DNAemia and/or pp65 antigenemia have been observed during pre-emptive ganciclovir therapy in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). We assessed the incidence of this event in our series, and investigated whether its occurrence was associated with an impairment in the CMV-specific T-cell response. A total of 36 allo-SCT recipients experienced one or more episodes of active CMV infection (n=68) that were pre-emptively treated with val(ganciclovir). Rising levels of antigenemia and DNAemia, and an isolated increase in antigenemia, were observed in 39.7 and 2.9% of all episodes, respectively. Receipt of corticost…

AdultCD4-Positive T-LymphocytesMaleGanciclovirAdolescentvirusesCongenital cytomegalovirus infectionCytomegalovirusCD8-Positive T-LymphocytesOpportunistic Infectionsmedicine.disease_causeHerpesviridaeImmediate-Early ProteinsViral Matrix ProteinsInterferon-gammaYoung AdultAntigenBetaherpesvirinaeDrug Resistance ViralmedicineHumansTransplantation HomologousAntigens ViralGanciclovirAgedTransplantationbiologybusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesHematologyMiddle AgedPhosphoproteinsbiology.organism_classificationmedicine.diseaseTransplantationsurgical procedures operativeCytomegalovirus InfectionsDNA ViralMutationImmunologyFemaleStem cellbusinessCD8medicine.drugBone Marrow Transplantation
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Functional patterns of cytomegalovirus (CMV) pp65 and immediate early-1-specific CD8+T cells that are associated with protection from and control of …

2015

Background The functional profile of cytomegalovirus (CMV)-specific CD8+ T cells that associate with protection from and control of CMV DNAemia in allogeneic stem cell transplant (allo-SCT) recipients remains incompletely characterized. Methods We enumerated pp65 and immediate early (IE)-1-specific CD8+ T cells expressing interferon-gamma, tumor necrosis factor-alpha, and CD107a, by flow cytometry in 94 patients at days +30 and +60 after allo-SCT. Results Fifty of 94 patients had CMV DNAemia within the first 100 days after transplant. CMV-specific CD8+ T-cell responses (of any functional type) were more likely to be detected in patients who did not display CMV DNAemia than in those who did …

AdultMaleAdolescentCongenital cytomegalovirus infectionCytomegalovirusCD8-Positive T-LymphocytesLower riskFlow cytometryCohort StudiesViral Matrix ProteinsInterferon-gammaYoung AdultmedicineHumansTransplantation HomologousCytotoxic T cellAgedTransplantationmedicine.diagnostic_testTumor Necrosis Factor-alphabusiness.industryvirus diseasesMiddle AgedPhosphoproteinsmedicine.diseaseVirologyTransplantationInfectious DiseasesCytomegalovirus InfectionsDNA ViralImmunologyFemaleTumor necrosis factor alphaStem cellbusinessCD8Stem Cell TransplantationTransplant Infectious Disease
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