0000000000135336
AUTHOR
Peter Möller
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.
SummaryImmunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and nonimmune origin. Here, we show that targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and mucosal tissues by a genotoxic Trp53-dependent mechanism. Cre-mediated mast cell eradication (Cre-Master) mice had, with the exception of a lack of mast cells and reduced basophils, a normal immune system. Cre-Master mice were refractory to IgE-mediated anaphylaxis, and this defe…
[18F]5-fluoro-2-deoxyuridine-PET for imaging of malignant tumors and for measuring tissue proliferation
The nucleoside 5-fluoro-2-deoxyuridine is a pyrimidine analogue accumulating in proliferative cells. We prospectively evaluated biodistribution of the PET tracer [(18)F]5-fluoro-2-deoxyuridine (FdUrd), its value for imaging malignant tumors, and its correlation to both [(18)F]2-fluoro-2-deoxyglucose (FDG)-PET findings and histological proliferation indices. In 11 previously untreated patients (5 lung carcinoma; 3 soft tissue sarcoma; 2 gastrointestinal carcinoma; 1 non-Hodgkin lymphoma [NHL]), mean doses of 290 MBq FdUrd and 390 MBq FDG were administered intravenously on subsequent days. Static PET scans were initiated 50-70 min after administration and the mean standardized uptake values (…
The Astrophysical r-process
In 1957, Burbidge, Burbidge, Fowler and Hoyle (B2FH) provided a basis for forty years of research in various aspects of nucleosynthesis in stars. We will focus in this paper on progress in r-process nucleosynthesis, with emphasis on the most recent developments in nuclear physics. In 1986, the first experimental data on two crucial, neutron-magic “waiting-point” nuclei provided valuable clues to the astrophysical conditions and the nature of the r-process site. Beginning in the 1990’s, our group (FK2L) presented considerably improved r-abundance calculations, which were for the first time based on a modern, internally consistent nuclear-theory input. The phenomenon of shell-quenching far fr…
Status of delayed-neutron precursor data: half-lives and neutron emission probabilities
Abstract We present in this paper a compilation of the present status of experimental delayed-neutron precursor data; i.e. β-decay half-lives ( T 1/2 ) and neutron emission probabilities ( P n ) in the fission-product region (27 ≤ Z ≤ 57). These data are compared to two model predictions of substantially different sophistication: (i) an update of the empirical Kratz-Herrmann formula (KHF), and (ii) a unified macroscopic-microscopic model within the quasi-particle random-phase approximation (QRPA). Both models are also used to calculate so far unknown T 1/2 and P n values up to Z = 63. A number of possible refinements in the microscopic calculations are suggested to further improve the nucle…
Calculation of beta-decay properties of neutron-rich nickel isotopes
Gamow-Tellerβ-decay properties of neutron-rich Ni isotopes have been calculated in the RPA with Nilsson model wave functions. On the basis of the results for the known isotopes67–69Ni, half-lives and neutron-emission probabilities for70–82Ni are predicted and compared to earlier model estimates. Possible implications onr-process nucleosynthesis are discussed.
NUCLEAR PROPERTIES FOR ASTROPHYSICAL AND RADIOACTIVE-ION-BEAM APPLICATIONS
Abstract We tabulate the ground-state odd-proton and odd-neutron spins and parities, proton and neutron pairing gaps, one- and two-neutron separation energies, quantities related to β -delayed one- and two-neutron emission probabilities, average energy and average number of emitted neutrons, β -decay energy release and half-life with respect to Gamow–Teller decay with a phenomenological treatment of first-forbidden decays, one- and two-proton separation energies, and α -decay energy release and half-life for 9318 nuclei ranging from 16O to 339136 and extending from the proton drip line to the neutron drip line. This paper is a new and improved version of Atomic Data And Nuclear Data Table…
Gamow-Teller decay ofZn80: Shell structure and astrophysical implications
Gamow-Teller \ensuremath{\beta} decay of $^{80}\mathrm{Zn}$ to levels in $^{80}\mathrm{Ga}$ has been calculated from a random-phase-approximation shell model with Nilsson model wave functions. The predicted features are compared to existing experimental results. Gross \ensuremath{\beta}-decay properties as well as quasiparticle structure indicate shape coexistence for $^{80}\mathrm{Ga}$. This result implies a rather rapid weakening of the shell strength far from \ensuremath{\beta} stability above $_{28}^{78}\mathrm{Ni}_{50}$. The nuclear properties of $^{80}\mathrm{Zn}$ as an astrophysical ``waiting-point'' nucleus suggest that the r-process scenario which is responsible for the solar r abu…
New calculations of grossβ-decay properties for astrophysical applications: Speeding-up the classicalrprocess
Recent compilations of experimental gross $\ensuremath{\beta}$-decay properties, i.e., half-lives ${(T}_{1/2})$ and neutron-emission probabilities ${(P}_{\mathrm{n}}),$ are compared to improved global macroscopic-microscopic model predictions. The model combines calculations within the quasiparticle (QP) random-phase approximation for the Gamow-Teller (GT) part with an empirical spreading of the QP strength and the gross theory for the first-forbidden part of ${\ensuremath{\beta}}^{\ensuremath{-}}$ decay. Nuclear masses are either taken from the 1995 data compilation of Audi et al., when available, otherwise from the finite-range droplet model. Especially for spherical and neutron-(sub-)mag…
β-decay half-lives andβ-delayed neutron emission probabilities of nuclei in the regionA≲110, relevant for the r process
Measurements of $\ensuremath{\beta}$-decay properties of $A\ensuremath{\lesssim}110$ r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory at Michigan State University. $\ensuremath{\beta}$-decay half-lives for $^{105}\mathrm{Y}$, $^{106,107}\mathrm{Zr}$, and $^{111}\mathrm{Mo}$, along with $\ensuremath{\beta}$-delayed neutron emission probabilities of $^{104}\mathrm{Y}$, $^{109,110}\mathrm{Mo}$ and upper limits for $^{105}\mathrm{Y}$, $^{103\ensuremath{-}107}\mathrm{Zr}$, and $^{108,111}\mathrm{Mo}$ have been measured for the first time. Studies on the basis of the quasi-random-phase approximation are used to analyze the ground-state deformation of these…
Beta-decay properties of the neutron-rich $^{94-99}$Kr and $^{142-147}$Xe isotopes
Beta-decay half-lives and delayed-neutron emission probabilities of the neutron-rich noble-gas isotopes Kr94-99 and Xe142-147 have been measured at the PSB-ISOLDE facility at CERN. The results are compared to QRPA shell-model predictions and are used in dynamic calculations of r-process abundances of Kr and Xe isotopes. (C) 2002 Elsevier Science B.V. All rights reserved.
Neutron-rich isotopes around the r-process ?waiting-point? nuclei 29 79 Cu50 and 30 80 Zn50
Beta-decay half-lives (T1/2) and delayed-neutron emission probabilities (Pn) of very neutron-rich Cu to As nuclei have been measured, among them the new isotopes77Cu48,79Cu50,81Zn51 and84Ga53. With the T1/2 and Pn-values of now four N ∼-50 ”waiting-point” nuclei known, our hypothesis that the r-process has attained a local β-flow equilibrium araound A∼-80 is further strengthened.
Onset of deformation in neutron-rich krypton isotopes
Beta-decay properties of neutron-rich35Br isotopes confirm the predicted smooth onset of quadrupole deformation for Z<37 already below N=60. The observed increase of the energy of the first 2+ state in the N=56 nucleus92Kr may indicate octupole softness.