Cigarette smoke upregulates TLR4 expression and enhances TLR4 mediated responses

Cigaretta smoke up-regulates toll like receptor 4 (TLR4) expression and enhances TLR4 mediated responses

Altered expression of TLR4 and beta 2 defensin in chronic obstructive pulmonary disease

Cigarette smoke up-regulates toll like receptor 4 (TLR4) expression and enhances TLR4 mediated responses

Functional role of PAR-1 receptors in the epithelial cells of smokers with and without COPD: involvement of intracellular signal pathways.

Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells.

Role of PGE2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis

Abstract The recurrence of pleural effusions is a common event in a variety of neoplastic diseases. The objective of this study was to identify the mechanisms promoting the homing and growth of cancer cells within the pleural space. A cancer cell line recovered from malignant pleural fluids (lung adenocarcinoma cell line) that constitutively expresses cyclooxygenase 2 (COX-2) and all types of prostaglandin receptors was studied. It was first demonstrated using a matrigel system, that malignant pleural fluids increase the invasiveness of adenocarcinoma cells more than congestive heart failure (CHF) pleural fluids. Moreover, exposure to exudative malignant, but not to CHF pleural fluids, incr…

The release of PGE2 by pleural macrophage prolongs the survival of T lymphocytee within the inflamed human pleural space

Functional role of PAR-1 receptors in the epithelial cells of smokers with and without COPD: involvement of intracellular pathway