0000000000138304
AUTHOR
Delphine Rousseau
Dietary n-3 PUFAs affect the blood pressure rise and the cardiac function modulation in a hyperinsulinemia rat model in vivo
National audience; This study was designed to assess in vivo the cardiovascular consequences of a dietary docosahexaenoic (DHA) or eicosapentaenoic (EPA) acid specific intake in a hyperinsulinemia (HI) model presented by fructose-induced insulin-resistant rats. Wistar rat (n=6 in each dietary group of control or HI rats) were fed for two months a diet containing 62% fructose, and supplemented (or not for control, NFD) with either DHA or EPA (240 mg per day). Modifications of the cardiovascular parameters (rise in blood pressure (BP), heart rate (HR), modulation, ECG) were continously monitored using an intra-abdominal implanted telemetry system in HI rats. The myocardial phospolipid fatty a…
Evaluation des effets d’un apport alimentaire en acides α-linolénique ou docosahexaénoïque sur les profils en acides gras des membranes et leurs conséquences cardiaques chez le rat in vivo
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Effet à long terme d’un apport alimentaire en acides α-linolénique ou docosahexaénoïque sur l’incorporation membranaire du DHA et ses conséquences cardiaques chez le rat in vivo
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Influence du DHA alimentaire sur les fonctions cardiovasculaires chez le rat SHR in vivo
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Long term effect of dietary alpha-linolenic (ALA) or docosahexaenoic acid (DHA) on the incorporation of of DHA and its influence in vivo on the rat heart
National audience; The present study was designed to evaluate if a high (20% of the fatty acids) and long term supply of dietary ALA as supplied in the diet by whole grain extruded linseed (Valorex) can increase the endogenous pro- duction of the long-chain n-3 PUFAs in healthy adult rats, and influence heart rate and adrenergic response like a DHA-rich diet. The enrichment in DHA was evaluated using fatty acid analysis by GC in various membranes (heart, brain, .. .) after 2, 4, 6 and 8 months of feeding (n = 7) from male Wistar rats randomly assigned to three groups (n = 36) and fed a normal fat diet (NFD), a ALA-rich diet (ALA) or a DHA-rich diet (DHA). In parallel three groups (n = 8) we…
Influence du DHA alimentaire sur la fonction cardiovasculaire chez le rat SHR in vivo
National audience