0000000000139720
AUTHOR
Frank Hampel
Anticancer Effect of an Electronically Coupled Oligoferrocene
The mode of anticancer activity of simple ferrocenes often relies on their intracellular oxidation with the formation of cytotoxic ferrocenium species. The former compounds should be considered as ...
Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin
Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquinone and artemisinin and evaluation of their activities against P. falciparum 3D7 parasites, human cytomegalovirus, sensitive and multidrug-resistant human leukemia cells. Most of the new hybrids exceed their parent compounds in antimalarial, antiviral and antileukemia activities and in some cases show higher in vitro efficacy than clinically used reference drugs chloroquine, ganciclovir and doxorubicin. Combined, our findings stress the high pot…
New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
Abstract In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard drugs, we present the synthesis and biological investigations of 2nd generation 1,2,4-trioxane-ferrocene hybrids. In vitro tests against the CCRF-CEM leukemia cell line revealed di-1,2,4-trioxane-ferrocene hybrid 7 as the most active compound (IC50 of 0.01 μM). Regarding the activity against the multidrug resistant subline CEM/ADR5000, 1,2,4-trioxane-ferrocene hybrid 5 showed a remarkable activity (IC50 of 0.53 μM). Contrary to the antimalaria activity of hybrids 4–8 against Plasmodium falciparum …
Self-assembly of 1D- and 3D-networks through non-coordination intermolecular forces: synthesis and crystal structures of copper(I) complexes based on pyridazine-type ligands
Reaction of [Cu2(H3CCN)2(μ-pydz)3][PF6]2 (1) with an excess of pyridazine or phthalazine yielded the novel dinuclear complexes [Cu2(μ-pydz)3(pydz)2][PF6]2 (2) and [Cu2 (μ- pydz)(μ-phtz)2(phtz)2][PF6]2 (5), respectively. Depolymerisation of the coordination polymer 1 ∞ {[Cu(μ-pydz)2][PF6]} (3) in dichloromethane by addition of an excess of benzo[c]cinnoline afforded the dinuclear copper(I) salt [Cu2(μ-pydz)2(pydz)2(benzo[c]cinnoline)2][PF6]2 (4). Furthermore, a new route for the preparation of bis(benzonitrile)tris(μ-phthalazine)dicopper(I) bis(trifluoromethanesulfonate), [Cu2(C6H5CN)2(μ-phtz)3][CF3SO3]2 (7), was established from {[Cu(CF3SO3)]2 ・C6H5Me}, phthalazine and benzonitrile via the …
CCDC 1993737: Experimental Crystal Structure Determination
Related Article: Gina Zeh, Philipp Haines, Matthias E. Miehlich, Torben Kienz, Andreas Neidlinger, Ralf P. Friedrich, Hülya G. Özkan, Christoph Alexiou, Frank Hampel, Dirk M. Guldi, Karsten Meyer, Jürgen Schatz, Katja Heinze, Andriy Mokhir|2020|Organometallics|39|3112|doi:10.1021/acs.organomet.0c00306
CCDC 1816140: Experimental Crystal Structure Determination
Related Article: Aysun Çapcı Karagöz, Christoph Reiter, Ean-Jeong Seo, Lisa Gruber, Friedrich Hahn, Maria Leidenberger, Volker Klein, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Thomas Efferth, Svetlana B. Tsogoeva|2018|Bioorg.Med.Chem.|26|3610|doi:10.1016/j.bmc.2018.05.041
CCDC 1993738: Experimental Crystal Structure Determination
Related Article: Gina Zeh, Philipp Haines, Matthias E. Miehlich, Torben Kienz, Andreas Neidlinger, Ralf P. Friedrich, Hülya G. Özkan, Christoph Alexiou, Frank Hampel, Dirk M. Guldi, Karsten Meyer, Jürgen Schatz, Katja Heinze, Andriy Mokhir|2020|Organometallics|39|3112|doi:10.1021/acs.organomet.0c00306
CCDC 1816139: Experimental Crystal Structure Determination
Related Article: Aysun Çapcı Karagöz, Christoph Reiter, Ean-Jeong Seo, Lisa Gruber, Friedrich Hahn, Maria Leidenberger, Volker Klein, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Thomas Efferth, Svetlana B. Tsogoeva|2018|Bioorg.Med.Chem.|26|3610|doi:10.1016/j.bmc.2018.05.041
CCDC 994084: Experimental Crystal Structure Determination
Related Article: Christoph Reiter, Tony Fröhlich, Maen Zeino, Manfred Marschall, Hanife Bahsi, Maria Leidenberger, Oliver Friedrich, Barbara Kappes, Frank Hampel, Thomas Efferth, Svetlana B. Tsogoeva|2015|Eur.J.Med.Chem.|97|164|doi:10.1016/j.ejmech.2015.04.053
CCDC 994085: Experimental Crystal Structure Determination
Related Article: Christoph Reiter, Tony Fröhlich, Maen Zeino, Manfred Marschall, Hanife Bahsi, Maria Leidenberger, Oliver Friedrich, Barbara Kappes, Frank Hampel, Thomas Efferth, Svetlana B. Tsogoeva|2015|Eur.J.Med.Chem.|97|164|doi:10.1016/j.ejmech.2015.04.053