Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the i…

Standardization and validation of a new method based on pre-concentration techniques

L'emergenza-urgenza psichiatrica nell'ospedale generale. Indagine epidemiologica e raffronto tra il Policlinico Universitario e l'SPDC dell'Ospedale "V. Cervello" di Palermo nella progettualità di un collegamento tra le diverse strutture nella gestione di servizi acuzie, post-acuzie, e non-acuzie