0000000000141023
AUTHOR
Chiaramonte M.
Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma.
Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients. Background & Aims: Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to …
FRESHWATER CYANOBACTERIA, IDENTIFIED BY MICROSCOPIC AND MOLECULAR INVESTIGATIONS ON A COLONIZED FOUNTAIN SURFACE: A CASE STUDY IN PALERMO (SICILY, ITALY)
Cyanobacteria or blue algae are ubiquitously present in both fresh and brackish water environments. They also grow in conditions of high humidity, colonizing stones or monuments and fountain surfaces, and creating thick biofilms able to induce biodeterioration in the constituent materials of artefacts. As well as several photoautotrophic organisms, cyanobacteria belong to the microorganisms identified as primary colonizers, playing an important role in stone artwork deterioration. In this study, an analysis was made of the biofilm collected from the stone fountain of the Two Dragons in Palermo (Italy), revealing the presence of cyanobacterial colonies by optical microscopy, due to their pec…
Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study
The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period…