0000000000141243
AUTHOR
Hao Chen
showing 15 related works from this author
Inhibitory Effect of Kurarinone on Growth of Human Non-small Cell Lung Cancer: An Experimental Study Both in Vitro and in Vivo Studies
2018
Kurarinone, a flavonoid isolated from Sophora flavescens Aiton, has been reported to have significant antitumor activity. However, the cytotoxic activity of kurarinone against non-small cell lung cancer (NSCLC) cells is still under explored. In our study, we have evaluated the inhibitory effects of kurarinone on the growth of NSCLC both in vivo and in vitro as well as the molecular mechanisms underlying kurarinone-induced A549 cell apoptosis. The results showed that kurarinone effectively inhibited the proliferation of A549 cells with little toxic effects on human bronchial epithelial cell line BEAS-2B. FASC examination and Hoechst 33258 staining assay showed that kurarinone dose-dependentl…
Two Methods to Broaden the Bandwidth of a Nonlinear Piezoelectric Bimorph Power Harvester
2017
We propose two methods to broaden the operation bandwidth of a nonlinear pinned–pinned piezoelectric bimorph power harvester. The energy-scavenging structure consists of a properly poled and electroded flexible bimorph with a metallic layer in the middle, and is subjected to flexural vibration. Nonlinear effects at large deformations near resonance are considered by taking the in-plane extension of the bimorph into account. The resulting output powers are multivalued and exhibit jump phenomena. Two methods to broaden the operation bandwidth are proposed: The first method is to extend the operation frequency to the left single-valued region through optimal design. The second method is to exc…
Multiple low-frequency broad band gaps generated by a phononic crystal of periodic circular cavity sandwich plates
2017
Abstract We propose a new type of phononic crystal (PnC) composed of a periodic alternation of circular cavity sandwich plates. In the low-frequency regime, the crystal can modulate the propagation of flexural waves. Governing equations are deduced basing on the classical theory of coupled extensional and flexural vibrations of plates. The dispersion relation of the infinite PnC is calculated by combining the transfer matrix method with Bloch theory. The dynamic response of the PnC with finite unit cells is further studied with finite element analysis. An experiment is carried out to demonstrate the performance of the PnC in vibration isolation. Numerical results and experimental results bo…
N-Acyl-glutarimides: Effect of Glutarimide Ring on the Structures of Fully Perpendicular Twisted Amides and N–C Bond Cross-Coupling
2020
N-Acyl-glutarimides have emerged as the most reactive precursors for N-C(O) bond cross-coupling reactions to date, wherein the reactivity is driven by ground-state destabilization of the amide bond. Herein, we report a full study on the effect of a glutarimide ring on the structures, electronic properties, and reactivity of fully perpendicular N-acyl-glutarimide amides. Most notably, this report demonstrates the generality of deploying N-acyl-glutarimides to achieve full twist of the acyclic amide bond, and results in the discovery of N-acyl-glutarimide amide with an almost perfect twist value, τ = 89.1°. X-ray structures of five new N-acyl-glutarimides are reported. Reactivity studies in t…
Air pollution perception in ten countries during the COVID-19 pandemic.
2021
As largely documented in the literature, the stark restrictions enforced worldwide in 2020 to curb the COVID-19 pandemic also curtailed the production of air pollutants to some extent. This study investigates the perception of the air pollution as assessed by individuals located in ten countries: Australia, Brazil, China, Ghana, India, Iran, Italy, Norway, South Africa and the USA. The perceptions towards air quality were evaluated by employing an online survey administered in May 2020. Participants (N = 9394) in the ten countries expressed their opinions according to a Likert-scale response. A reduction in pollutant concentration was clearly perceived, albeit to a different extent, by all …
Comparative study of indirect tensile test and uniaxial compression test on asphalt mixtures: Dynamic modulus and stress-strain state
2023
Dynamic modulus is an essential parameter for the performance characterisation of asphalt materials for performance prediction and pavement design. The Indirect Tensile (IDT) test and the Uniaxial Compression (UC) test are both well-known experiments performed in the laboratory to characterise the dynamic modulus of asphalt mixtures over a range of temperatures and loading frequencies. A considerable amount of research has investigated the difference between two test modes, while few studies analysed the fundamental difference in stress–strain distributions for the two test setups. This work aims at comparing the effect of the two test methods on dynamic modulus of asphalt mixtures, as well…
Evaluation of Cyclic Amides as Activating Groups in N-C Bond Cross-Coupling: Discovery of N-Acyl-δ-valerolactams as Effective Twisted Amide Precursor…
2021
The development of efficient methods for facilitating N-C(O) bond activation in amides is an important objective in organic synthesis that permits the manipulation of the traditionally unreactive amide bonds. Herein, we report a comparative evaluation of a series of cyclic amides as activating groups in amide N-C(O) bond cross-coupling. Evaluation of N-acyl-imides, N-acyl-lactams, and N-acyl-oxazolidinones bearing five- and six-membered rings using Pd(II)-NHC and Pd-phosphine systems reveals the relative reactivity order of N-activating groups in Suzuki-Miyaura cross-coupling. The reactivity of activated phenolic esters and thioesters is evaluated for comparison in O-C(O) and S-C(O) cross-c…
Validation of the Weight Bias Internalization Scale for Mainland Chinese Children and Adolescents
2021
Weight stigma internalization among adolescents across weight categories leads to adverse psychological consequences. This study aims to adapt and validate a Chinese version of the Weight Bias Internalization Scale for Mainland Chinese children and adolescents(C-WBIS). A total of 464 individuals aged 9 to 15 years participated in the present study. Based on item response theory (IRT) and classical test theory (CTT), we selected the items for the C-WBIS and evaluated its reliability and validity. The item response theory yields support for the one-dimensional factor mode. All item parameters fit the IRT model (albeit within an adequate range), eight items were adopted. No evidence of signifi…
Impact of COVID-19 pandemic on mobility in ten countries and associated perceived risk for all transport modes.
2021
The restrictive measures implemented in response to the COVID-19 pandemic have triggered sudden massive changes to travel behaviors of people all around the world. This study examines the individual mobility patterns for all transport modes (walk, bicycle, motorcycle, car driven alone, car driven in company, bus, subway, tram, train, airplane) before and during the restrictions adopted in ten countries on six continents: Australia, Brazil, China, Ghana, India, Iran, Italy, Norway, South Africa and the United States. This cross-country study also aims at understanding the predictors of protective behaviors related to the transport sector and COVID-19. Findings hinge upon an online survey con…
CCDC 1969088: Experimental Crystal Structure Determination
2020
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 2082397: Experimental Crystal Structure Determination
2021
Related Article: Md. Mahbubur Rahman, Daniel J. Pyle, Elwira Bisz, Bażej Dziuk, Krzysztof Ejsmont, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2021|J.Org.Chem.|86|10455|doi:10.1021/acs.joc.1c01110
CCDC 1969085: Experimental Crystal Structure Determination
2020
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969087: Experimental Crystal Structure Determination
2020
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969082: Experimental Crystal Structure Determination
2020
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969086: Experimental Crystal Structure Determination
2020
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227