0000000000141482

AUTHOR

Matti Lehtinen

showing 3 related works from this author

Prospective seroepidemiologic study of human papillomavirus infection as a risk factor for invasive cervical cancer

1997

Background: Major risk factors for invasive cervical cancer include infection with human papillomavirus (HPV), infection with other sexually transmitted pathogens (e.g., Chlamydia trachomatis), and smoking. Since exposures to these risk factors can be related, the contribution of any single factor to cervical carcinogenesis has been difficult to assess. We conducted a prospective study to define the role of HPV infection in cervical carcinogenesis, with invasive cancer as an end point. Methods: A nested case‐control study within a joint cohort of 700 000 Nordic subjects was performed. The 182 women who developed invasive cervical cancer during a mean follow-up of 5 years were matched with 5…

AdultRiskCancer Researchmedicine.medical_specialtyRadioimmunoassaySexually Transmitted DiseasesUterine Cervical NeoplasmsAdenocarcinomamedicine.disease_causeSerology03 medical and health sciences0302 clinical medicineRisk FactorsSeroepidemiologic StudiesInternal medicinePrevalencemedicineHumansNeoplasm InvasivenessProspective Studies030212 general & internal medicinePapillomaviridaeRisk factorPapillomaviridaeGynecologyCervical cancerbiologybusiness.industryIncidencePapillomavirus InfectionsHPV infectionCancerMiddle Agedbiology.organism_classificationmedicine.disease3. Good healthTumor Virus InfectionsOncologyCase-Control Studies030220 oncology & carcinogenesisRelative riskCarcinoma Squamous CellFemalebusinessChlamydia trachomatis
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Sero-epidemiologal association between human-papillomavirus infection and risk of prostate cancer

1998

Some epidemiological studies of prostate cancer have suggested the existence of a sexually transmitted risk factor, and some studies have reported the presence of human papillomavirus (HPV) DNA in prostate-cancer tissue. To perform a sero-epidemiological evaluation of whether HPV infection is associated with increased risk for prostate cancer, we performed a nested case-control study within a serum bank containing samples from 20,243 healthy Finnish men. We identified 165 cases of prostate cancer that were diagnosed up to 24 years after donation of the serum sample. Two control subjects per case were selected, matched for gender, age and municipality of residence. Serum samples were analyze…

OncologyCancer Researchmedicine.medical_specialtyChlamydiabusiness.industryCase-control studyHPV infectionmedicine.diseaseSerologyProstate cancermedicine.anatomical_structureOncologyProstateRelative riskInternal medicineImmunologymedicineRisk factorbusinessInternational Journal of Cancer
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Lean-ohjelmistokehityksen käyttöönoton jälkeisiä ohjelmistokehitysnopeutta rajoittavia tekijöitä

2011

Tutkielmassa tarkastellaan, mitä Lean ja Lean-ohjelmistokehitys ovat, mitä Lean-ohjelmistokehitys tarkoittaa tapausyrityksessä, eli Sysdrone Oy:ssä, sekä mitkä ovat tapausyrityksen merkittävimmät ohjelmistokehitysnopeutta rajoittavat tekijät puoli vuotta Lean-ohjelmistokehityksen käyttöönoton jälkeen. Tutkimus toteutettiin tapaustutkimuksena, jossa tutkimusaineistoa kerättiin puolen vuoden aikajaksolta. Johtopäätöksinä merkittävimmiksi rajoittaviksi tekijöiksi tunnistettiin tuotoslista, uudet teknologiat, projektien riittämätön läpinäkyvyys, tiettyjen hen-kilöiden ylikuormitus, puutteet prosessien noudattamisessa, dokumentointi sekä asiakaskommunikaatio.

Lean-ohjelmistokehitysvirtausohjelmistokehitysarvo
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