0000000000142756

AUTHOR

Viña Jose

showing 3 related works from this author

Overexpression of G6PD as a model of robustness

2018

Introduction Frailty is a major geriatric syndrome that has been associated to oxidative stress. The antioxidant system is largely based on the reducing power of NADPH, whose levels are mainly determined by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Material and methods Using old female Tg-mice overexpressing G6PD (18 to 26 months old), we measured frailty and different muscle parameters: oxidative stress, cross-sectional area (CSA), markers regulating protein synthesis, mitochondrial dynamics, and apoptosis. Results Our results show that 18–24 months old G6PD-Tg animals performed better in the motor coordination and grip strength test than the WT. We also found lower changes in b…

medicine.medical_specialtyAntioxidantmedicine.medical_treatment[SDV]Life Sciences [q-bio]Dehydrogenasemedicine.disease_causeBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePhysiology (medical)AdipocyteInternal medicinehemic and lymphatic diseasesmedicine030304 developmental biologychemistry.chemical_classification0303 health sciencesGlutathione3. Good healthMotor coordinationEndocrinologyEnzymechemistryApoptosis030217 neurology & neurosurgeryOxidative stress
researchProduct

Early reductive stress followed by a late onset oxidative stress in acute myocardial infarction

2018

Introduction The idea that the cells might suffer from reductive rather than oxidative stress and that such stress may be relevant in pathophysiology has gained momentum. Aim We aimed at studying markers of oxidative stress and damage as well as the expression of antioxidant enzymes in a swine model of acute myocardial infarction (AMI) followed by reperfusion. Results and Discussion We found an increase in the GSH to GSSG ratio, a decrease in protein glutathionylation and a decrease in p38 MAPK phosphorylation after 90 minutes of ischaemia in heart samples. It was accompanied by an increase in the expression of Thioredoxin (TrX) and Peroxiredoxin (PrX) and a decrease in the expression of Gl…

chemistry.chemical_classificationmedicine.medical_specialtyProtein CarbonylationGlutathione peroxidaseGlutathione reductaseGlutathioneProtein glutathionylationmedicine.disease_causeBiochemistryLipid peroxidationchemistry.chemical_compoundEndocrinologychemistryPhysiology (medical)Internal medicinemedicineThioredoxinOxidative stressFree Radical Biology and Medicine
researchProduct

Centenarians, but not octogenarians, up-regulate the expression of microRNAs

2012

Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations in small non-coding RNA expression. We report the first comparison of microRNAs expression profiles in mononuclear cells from centenarians, octogenarians and young individuals resident near Valencia, Spain. Principal Component Analysis of the expression of 15,644 mature microRNAs and, 2,334 snoRNAs and scaRNAs in centenarians revealed a significant overlap with profiles in you…

Aged 80 and overGeneticsRegulation of gene expressionAgingPrincipal Component AnalysisRNA UntranslatedMultidisciplinaryGene Expression Profilingmedia_common.quotation_subjectLongevityLongevityBiologyArticleUp-RegulationGene expression profilingMicroRNAsRna expressionSpainmicroRNAExtreme longevity trackingHumansRNA Small NucleolarSmall nucleolar RNAmedia_commonScientific Reports
researchProduct