0000000000143630

AUTHOR

David Engblom

showing 3 related works from this author

Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses

2017

Sickness responses to lipopolysaccharide (LPS) were examined in mice with deletion of the interleukin (IL)-1 type 1 receptor (IL-1R1). IL-1R1 knockout (1(0) mice displayed intact anorexia and HPA-axis activation to intraperitoneally injected LPS (anorexia: 10 or 120 mu g/kg; HPA-axis: 120 mu g/kg), but showed attenuated but not extinguished fever (120 g/kg). Brain PGE2 synthesis was attenuated, but Cox-2 induction remained intact. Neither the tumor necrosis factor-alpha (TNF alpha) inhibitor etanercept nor the IL -6 receptor antibody tocilizumab abolished the LPS induced fever in IL -1R1 KO mice. Deletion of IL -1R1 specifically in brain endothelial cells attenuated the LPS induced fever, b…

0301 basic medicineLipopolysaccharidesMalemedicine.medical_specialtyLipopolysaccharideFeverCell- och molekylärbiologiImmunologyHypothalamusAnorexiaEtanerceptInterleukin-1 type 1 receptor; Lipopolysaccharide; Fever; Anorexia; ACTH; Corticosterone; Endothelial cells; THF alpha; Interleukin-6; PGE(2)03 medical and health sciencesBehavioral Neurosciencechemistry.chemical_compoundEating0302 clinical medicineAdrenocorticotropic HormoneCorticosteroneInternal medicinemedicineJournal ArticleAnimalsInterleukin 6ReceptorIllness BehaviorInflammationMice KnockoutReceptors Interleukin-1 Type IbiologyEndocrine and Autonomic Systemsbusiness.industryInterleukinBrainEndothelial CellsAnorexia030104 developmental biologyEndocrinologychemistrybiology.proteinTumor necrosis factor alphaFemalemedicine.symptomInflammation MediatorsbusinessCorticosterone030217 neurology & neurosurgeryCell and Molecular Biologymedicine.drug
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Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting

2011

Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing RV diarrhoea but how RV can induce emesis, a hallmark of the illness, remains unresolved. In this study we have addressed the hypothesis that RV-induced secretion of serotonin (5-hydroxytryptamine, 5-HT) by enterochromaffin (EC) cells plays a key role in the emetic reflex during RV infection resulting in activation of vagal afferent nerves connected to nucleus of the solitary tract (NTS) and area postrema in the brain stem, structures associated with nausea and vomiting. Our experiments revealed that RV can infect and replicate in human…

RotavirusViral DiseasesViral Nonstructural ProteinsMiceChildlcsh:QH301-705.5Mice Inbred BALB CArea postremaBrainNauseaVagus NerveJejunumInfectious DiseasesMEDICINChild PreschoolEnterochromaffin cellVomitingMedicineSerotonin Antagonistsmedicine.symptomProto-Oncogene Proteins c-fosResearch Articlelcsh:Immunologic diseases. Allergymedicine.medical_specialtySerotoninVomitingImmunologyBiologyMicrobiologyRotavirus InfectionsSDG 3 - Good Health and Well-beingInternal medicineCell Line TumorVirologyGeneticsmedicineEnterochromaffin CellsAnimalsHumansBiologyMolecular BiologyGlycoproteinsToxins BiologicalMEDICINEVagus nerveEndocrinologyGene Expression Regulationlcsh:Biology (General)Cell cultureParasitologyEnteric nervous systemCalciumSerotoninlcsh:RC581-607Ex vivo
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Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.

2008

The persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (NAc). To identify the molecular processes leading to these adaptations, we performed Cre/loxP-mediated genetic ablations of two key regulators of gene expression in response to activity, the Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) and its postulated main target, the cAMP-responsive element binding protein (CREB). We found that acute cocaine-induced gene expression in the striatum was largely unaffected by the loss of CaMKIV. On the behavioral level, mice lacking CaMKIV in dopaminoceptive neurons displayed increased sensitivity to cocai…

AdultMalemedicine.medical_specialtymedia_common.quotation_subjectMice TransgenicStriatumBiologyNucleus accumbensCREBPolymorphism Single NucleotideCocaine-Related DisordersMiceInternal medicineGene expressionmedicineAnimalsHumansProtein kinase ACyclic AMP Response Element-Binding Proteinmedia_commonRegulation of gene expressionNeuronsAnalysis of VarianceMultidisciplinaryNeuronal PlasticityAddictionGene Expression ProfilingBiological SciencesMolecular biologyImmunohistochemistryConditioned place preferenceCorpus StriatumEndocrinologyGene Expression Regulationbiology.proteinFemaleBrazilCalcium-Calmodulin-Dependent Protein Kinase Type 4Gene DeletionProceedings of the National Academy of Sciences of the United States of America
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