Optimal local control and tolerability of three-dimensional conformal radiation therapy in prostate cancer: A single institutional experience of dose escalation in 125 patients

Aims To evaluate long-term late side effects, clinical and biochemical relapse in non-metastatic prostate cancer patients treated with dose escalation, from 74 to 78 Gy, by means of three dimensional conformal radiation therapy. Materials and Methods Clinical data of 125 patients with prostate cancer who underwent three-dimensional conformal radiation therapy were retrospectively evaluated. All patients were stratified, according to the NCCN classification, in low, intermediate and high risk, and all of them showed histologically proven adenocarcinoma stage T1–T3 with at least 2 years of follow-up. Late toxicity was analyzed using a modified Radiation Therapy Oncology Group toxicity scale. …

PREDICTIVE MODELS BASED ON RADIOMICS AND MACHINE LEARNING FOR LUNG CANCER RADIOTHERAPY DATA ANALYSIS

Use of alanine EPR dosimeters for discriminating neutron and photon components in the thermal column of Pavia Triga reactor

The main gol of the present work is to investigate the response behaviour of alanine EPR pellets in clinical proton anc carbon ion beams. Proton irradiations were carried out at PSI (Switzerland) using both passive and active scattering modality, whereas, C ions irradiation were performed at GSI (Germany) adopting the raster scanning modality.

Gel di Fricke: studio della risposta NMR in funzione della concentrazione di ferro ed utilizzo dosimetrico in ambito clinico (3D MRI)

Sensibilità e stabilità dei dosimetri gel di tipo Fricke esposti ai fotoni nel range clinico in funzione della concentrazione di ferro e degli additivi presenti: 3D MRI per applicazioni dosimetriche

Characterization of Fricke gel dosimeters exposed to clinical photons beams and of MRI dosimetrical applications

Phenol compounds as new materials for Electron Spin Resonance (ESR) dosimetry in clinical photon and electron beams

In the last decades several research laboratories have shown an increasing interest aimed at extending the applicability of Electron Spin Resonance (ESR) dosimetry to radiotherapy with different types of radiation beams. ESR is a spectroscopic method for investigating the structure and dynamics of such paramagnetic species. Free radicals are known to be produced when a compound is irradiated with ionizing radiations. The concentration of radiation-induced free radicals is proportional to the energy released inside in the medium and this allows for dosimetric measurements through ESR technique which able to quantitatively determine the radical concentration.The use of alanine as a dosimetric…

END-TO-END TEST IN STEREOTACTIC RADIOSURGERY TREATMENTS THROUGH HELICAL TOMOTHERAPY

Agarose and PVA Fricke gel dosimeters exposed to clinical photons beams: Nuclear Magnetic Resonance Relaxometry and Imaging

Fricke Xylenol Gel (FXG) dosimetric system is based on the radiation induced oxidation of ferrous (Fe2+) to ferric (Fe3+) ions. The application of Fricke gels for ionizing radiation dosimetry is continuously increasing worldwide due to their many favorable properties. However, one of their shortcomings is that ferrous and ferric ions diffuse in the gel matrix. To maintain the spatial integrity of the dose distribution, Fricke gels must be undergoing measurement within a few hours of their irradiation, so that ferric ions remain close to their point of production. Thus, the spatial integrity of the dose distribution in the Fricke gel is maintained. The gel matrix also contributes to the oxid…

Determinazione della componente fotonica all’interno della colonna termica del reattore TRIGA mediante letture ESR di dosimetri di alanina

ASPETTI OPERATIVI NELLA VALUTAZIONE DELLA DOSE AL CRISTALLINO DEI LAVORATORI NELLE PROCEDURE INTERVENTISTICHE DI EMODINAMICA.

Recenti studi epidemiologici hanno evidenziato una incidenza di complicanze oculari (cataratte), per esposizione alle radiazioni ionizzanti del cristallino, superiore a quanto ritenuto in passato. Nella sua pubblicazione del 21 aprile 2011 dal titolo “Statement on Tissue Reactions”, sugli effetti tissutali deterministici non cancerogeni delle radiazioni ionizzanti, l’ICRP indica per il cristallino una dose soglia di 0,5 Gy e raccomanda, per esposizioni lavorative, il limite annuale di 20 mSv di dose equivalente come media su un periodo di 5 anni, senza che sia mai superato il valore di 50 mSv in ogni singolo anno. Questo valore è di gran lunga inferiore all’attuale limite di legge che è par…