Microscopic calculations for rare beta decays

In this thesis consisting of six publications and an overview part, three cases of rare beta decays are studied using microscopic nuclear models. Firstly, the half-lives and electron spectra of 113Cd and 115In fourth-forbidden nonunique ground-state-to-ground-state beta decays are studied using two closely related nuclear models: The microscopic quasiparticle-phonon model (MQPM) and the proton-neutron MQPM (pnMQPM), which has been developed as a part of this thesis work. Our results for these rare decays are compared to the available experimental data and are found to agree reasonably well. As the second application, the partial half-lives of the yet unobserved single-beta decay channels co…

Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BSC) or Bsc Alone: Subanalysis of the Phase III Mission Trial

ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…

¹¹³Cd:n ja ¹¹⁵In:n perustilan beetahajoaminen MQPM-mallin avulla laskettuna