A rapid and quantitative technique to study striatal dopaminergic neurodegeneration by in vivo reverse microdialysis in rats

Selective stimulation of serotonin2c receptors blocks the enhancement of striatal accumbal dopamine release by nicotine administration

Serotonin 5-HT2C Receptor and Dopamine Function in Depression

Unilateral Nigral Lesion Induces Dramatic Bilateral Modification In Rat Brain Monoamine Levels: A Neurochemical Study.

ACETYLSALYCILIC ACID (ASA) PROTECTS AGAINST NEURONAL DAMAGE INDUCED BY 1-METHYL-4-PHENYLPYRIDINIUM IODIDE (MPP+) IN RAT STRIATUM: AN IN VIVO MICRODIALYSIS STUDY

ROLE OF CENTRAL 5-HT2C RECEPTOR IN THE CONTROLL OF BASAL GANGLIA FUNCTIONS

Role of nitric oxide on the conrol of the dopaminergic Nigrostriatal system: a combined electrophysiological And dialysis analysis in rats

Electrophysiological and Neurochemical In Vivo Studies on Serotonin 5-HT 2C Control of Central Dopaminergic Function

MUSCARINIC MODULATION OF THE ACTIVITY OF THE SUBSTANTIA NIGRA PARS COMPACTA NEURONS IN RATS: ROLE OF THE TEGMENTAL PEDUNCULOPONTINE NUCLEUS

7-Nitroindazole protects striatal neurons against MPP+ -induced degeneration.

The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). In this study, using a microdialysis technique, we investigated whether an inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitrindazole (7-NI), could protect against DAergic neuronal damage induced by in vivo infusion of 1-methyl-4-phenylpiridinium iodide (MPP+) in freely moving rats. Experiments were performed over 2 days in three groups of rats: (a) nonlesioned, (b) MPP+-lesioned, and (c) 7-NI pretreated MPP+-lesioned rats. On day 1, control rats were perfused with an artificial CSF, while 1 mM MPP+ was infused into t…

Serotonin-dopamine interaction: electrophysiological evidence.

In this review, the most relevant data regarding serotonin (5-hydroxytryptamine, 5-HT)/dopamine (DA) interaction in the brain, as studied by both in vivo and in vitro electrophysiological methods, are reported and discussed. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from 5-HT originating in the raphe nuclei of the brainstem. Furthermore, this modulation seems to be reciprocal; DA neurons innervate the raphe nuclei and exert a tonic excitatory effect on them. Compelling electrophysiological data show that 5-HT can exert complex effects on the electrical activity of midbrain DA neurons mediated by the va…

Involvement of nitric oxide in the nigrostriatal dopaminergic system degeneration: a study on the 6-OHDA model of Parkinson's disease.

The Life Cycle of the Dopaminergic Neurons in the Substantia Nigra

Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

ROLE OF CENTRAL 5-HT2C RECEPTOR IN THE CONTROLL OF BASAL GANGLIA FUNCTIONS.

Crucial Role of the 5-HT2C Receptor in Regulating the Activity of the Substantia Nigra Pars Reticulata Neurons: An Electrophysiological Study in Rats. 5th Forum of European Neuroscience - Vienna

The Pivotal Role of Nitric Oxide in 6-OHDA-induced Dopaminergic Neurotoxicity: Neurochemical Evidences in Rats

CRUCIAL ROLE OF THE 5-HT2C RECEPTOR IN REGULATING THE ACTIVITY OF THE SUBSTANTIA NIGRA PARS RETICULATA NEURONS: AN ELECTROPHYSIOLOGICAL STUDY IN RATS

Serotonin modulation of the basal ganglia circuitry : therapeutic implication for Parkinson’s disease and other motor disorders

Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all the basal ganglia nuclei. In fact, serotonergic terminals have been reported to make synaptic contacts with both substantia nigra dopamine-containing neurons and their terminal areas such as the striatum, the globus pallidus and the subthalamus. These brain areas contain a high concentration of serotonin (5-HT), with the substantia nigra pars reticulata receiving the greatest input. In this chapter, the d…

Preferential modulation of the gabaergic vs. dopaminergic function in the substantia nigra by 5-TH2C receptor signaling: electrophysiological and neurochemical evidence

Activation of 5-HT2C receptors stimulates GABA-ergic neurons of the rat substantia nigra pars reticulata: an in vivo microiontophoretic study.

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies

In this review, the functional interactions between serotonin (5-HT) and dopamine (DA) neuronal systems are discussed with the focus on microdialysis studies in the rodent brain (mainly rats). 5-HT by itself is involved both directly and indirectly via actions on complex neuronal circuitry, in the regulation of DA release through multiple 5-HT receptors, playing a critical role in the development of normal and abnormal behaviours. Recent evidence suggests that dysfunction of dopaminergic and serotoninergic neurotransmitter systems contributes to various disorders including depression, schizophrenia, Parkinson's disease and drug abuse. Here we summarize recent neurochemical works that have e…