0000000000145764

AUTHOR

Jean-robert Harlé

showing 2 related works from this author

Ophthalmic manifestations in IgG4-related disease

2017

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AdultAged 80 and overMaleEye Diseases3600Anti-Inflammatory AgentsObservational StudyMiddle AgedEyeYoung AdultrituximabImmune System DiseasesImmunoglobulin GComputingMethodologies_DOCUMENTANDTEXTPROCESSINGHumansPrednisoneFemaleIgG4-related diseaseorbital inflammatory pseudo-tumorIgG4-related dacryoadenitisIgG4-related ophthalmic diseaseResearch ArticleAgedRetrospective StudiesMedicine
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T cell Polarization toward T(H)2/T(FH)2 and T(H)17/T(FH)17 in Patients with IgG4-related Disease

2017

International audience; IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocyte's subsets were analyzed by flow cytometry, with analysis of T(H)1/T(H)2/T(H)17, T-FH cells, and cytokine release by peripheral blood mononuclear cells. Results were compared to healthy contro…

0301 basic medicinemedicine.medical_treatmentT cellImmunologyplasmablastsBiologyCXCR3Peripheral blood mononuclear cellFlow cytometry03 medical and health sciencesInterleukin 21T helper cellsmedicineImmunology and AllergyCytotoxic T cellIgG4-related diseaseB cellmedicine.diagnostic_test3. Good health030104 developmental biologyCytokinemedicine.anatomical_structureSjögren’s syndromeImmunologyT follicular helper cells[SDV.IMM]Life Sciences [q-bio]/Immunology
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