0000000000146775

AUTHOR

Bruno Spire

showing 3 related works from this author

Significant reductions in alcohol use after hepatitis C treatment: results from the ANRS CO13-HEPAVIH cohort

2017

BACKGROUND AND AIMS: Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving pegylated interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use. DESIGN: A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants' clinical data were retrieved from medical records and socio-demographic and behavioural characteristics were collected by yearly self-administered questionnaires. SETTING: Data were collected across 17 hospitals in France. PARTICIPANTS: All HIV-HCV co-infecte…

medicine.medical_specialtyHepatitis C virusMedicine (miscellaneous)Binge drinkingmedicine.disease_causeUnit of alcohol03 medical and health sciences0302 clinical medicinePegylated interferonInternal medicinemedicine030212 general & internal medicineProspective cohort studybiologybusiness.industryvirus diseasesHepatitis Cmedicine.diseasebiology.organism_classificationVirologydigestive system diseases3. Good healthPsychiatry and Mental healthCohort030211 gastroenterology & hepatologyCannabisbusinessmedicine.drugAddiction
researchProduct

Evolution of patients’ socio-behavioral characteristics in the context of DAA: Results from the French ANRS CO13 HEPAVIH cohort of HIV-HCV co-infecte…

2018

International audience; BACKGROUND:Direct-acting antivirals (DAA) have dramatically increased HCV cure rates with minimal toxicity in HIV-HCV co-infected patients. This study aimed to compare the socio-behavioral characteristics of patients initiating pegylated-interferon (PEG-IFN)-based HCV treatment with those of patients initiating DAA-based treatment.METHODS:ANRS CO13 HEPAVIH is a national multicenter prospective cohort started in 2005, which enrolled 1,859 HIV-HCV co-infected patients followed up in French hospital outpatient units. Both clinical/biological and socio-behavioral data were collected during follow-up. We selected patients with socio-behavioral data available before HCV tr…

RNA virusesMaleHealth BehaviorSocial Scienceslcsh:MedicineHIV InfectionsHepacivirusGeographical locationsChronic Liver Disease0302 clinical medicineRisk FactorsPrevalencePsychologyAlcohol consumptionProspective Studies030212 general & internal medicineYoung adultProspective cohort studylcsh:SciencePathology and laboratory medicinemedia_commonChronic hepatitisDrug injectionClinical Trials as TopicMultidisciplinarybiologyPharmaceuticsCoinfectionHepatitis C virusLiver Diseasesvirus diseasesMedical microbiologyMiddle AgedPrognosisHepatitis CAddicts3. Good healthEuropeBehavioral PharmacologyDrug usersVirusesCohortFemale030211 gastroenterology & hepatologyDrug therapyFrancePathogensResearch ArticleAdultDrugmedicine.medical_specialtySubstance-Related Disordersmedia_common.quotation_subjectLiver fibrosisAddictionContext (language use)Gastroenterology and HepatologyMicrobiologyAntiviral AgentsYoung Adult03 medical and health sciencesPharmacotherapyRecreational Drug UseInternal medicinemedicineHumansEuropean UnionNutritionAgedCannabisMedicine and health sciencesPharmacologyBiology and life sciencesFlavivirusesbusiness.industrylcsh:ROrganismsViral pathogensHIVbiology.organism_classificationHepatitis virusesdigestive system diseasesMicrobial pathogensDiet[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologielcsh:Q[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieCannabisPeople and placesbusiness
researchProduct

Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patien…

2012

Objective To investigate the relationship between response to antiretroviral therapy (ART), alcohol use and occurrence of a major coronary or other arterial disease event (CADE) in HIV-infected individuals. Design A cohort study. A Cox model was used to identify the correlates of a first occurrence of a major CADE. Setting The French ANRS CO8 APROCO-COPILOTE cohort was set up in 1997 to study clinical progression and patient-reported outcomes (PRO) after initiating a protease inhibitor-containing ART. Clinical data were retrieved from medical records. Self-administered questionnaires collected data on PRO and behaviours, including alcohol use. Participants Metabolic data were only available…

1683Pathologymedicine.medical_specialtyArterial disease03 medical and health sciences0302 clinical medicineAcquired immunodeficiency syndrome (AIDS)Internal medicinemedicineHiv infected patients1506030212 general & internal medicine17060303 health sciences030306 microbiologyProportional hazards modelbusiness.industryResearchGeneral Medicinemedicine.diseaseAntiretroviral therapy3. Good healthInfectious DiseasesCohort1714businessAlcohol consumptionCohort studyBMJ Open
researchProduct