0000000000147199

AUTHOR

Silvia Mosulén

showing 2 related works from this author

ChemInform Abstract: Asymmetric Synthesis of Fluorinated Amino Macrolactones Through Ring-Closing Metathesis.

2008

The synthesis of new chiral fluorinated amino and azamacrolactones of types 1 and 2 is described. A ring-closing metathesis (RCM) reaction constitutes the key step in this methodology, which uses fluorinated amino alcohols 7 as starting materials. The influence of the CF2 group, which is located in the alpha-position relative to the carbon bearing the amino group, on the efficiency of the RCM reaction is noteworthy. This method allows for the preparation of the desired fluorinated macrolactones in excellent yields.

Ring-closing metathesisChemistryEnantioselective synthesisOrganic chemistryGeneral MedicineMetathesisChemInform
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Asymmetric synthesis of fluorinated amino macrolactones through ring-closing metathesis

2007

The synthesis of new chiral fluorinated amino and azamacrolactones of types 1 and 2 is described. A ring-closing metathesis (RCM) reaction constitutes the key step in this methodology, which uses fluorinated amino alcohols 7 as starting materials. The influence of the CF2 group, which is located in the alpha-position relative to the carbon bearing the amino group, on the efficiency of the RCM reaction is noteworthy. This method allows for the preparation of the desired fluorinated macrolactones in excellent yields.

chemistry.chemical_classificationModels MolecularMacrocyclic CompoundsHydrocarbons FluorinatedMolecular StructureOrganic ChemistryEnantioselective synthesisStereoisomerismStereoisomerismMetathesisCrystallography X-RayCombinatorial chemistryChemical synthesisAmino AlcoholsLactonesRing-closing metathesischemistryCyclizationMoleculeAmine gas treatingLactone
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