0000000000147947
AUTHOR
Davy Hayez
Mechanical ventilation alters the development of staphylococcus aureus pneumonia in rabbit
Ventilator-associated pneumonia (VAP) is common during mechanical ventilation (MV). Beside obvious deleterious effects on muco-ciliary clearance, MV could adversely shift the host immune response towards a pro-inflammatory pattern through toll-like receptor (TLRs) up-regulation. We tested this hypothesis in a rabbit model of Staphylococcus aureus VAP. Pneumonia was caused by airway challenge with S. aureus, in either spontaneously breathing (SB) or MV rabbits (n = 13 and 17, respectively). Pneumonia assessment regarding pulmonary and systemic bacterial burden, as well as inflammatory response was done 8 and 24 hours after S. aureus challenge. In addition, ex vivo stimulations of whole blood…
Mise au point d’un modèle de co-culture cellules entérocytes et d’un modèle de colonisation digestive stable chez la souris immuno-compétente permettant d’étudier les interactions cellulaires et moléculaires in vitro et in vivo de C. albicans avec la muqueuse digestive
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