0000000000154928
AUTHOR
Romano A
showing 45 related works from this author
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
Efficacia e tollerabilità dell'associazione caspofungin/amphotericina B liposomiale in pazienti con candidosi
2006
Considerazioni su un caso di schizosomiasi urinaria
2005
Diagnosis of congenital toxoplasmosis: pre-and post-natal evaluation in Sicilian (Italy) epidemiological area. Preliminary data.
2007
Infezioni invasive da Candida in gravi prematuri
2005
Morte cellulare programmata in oociti umani dopo ICSI
2005
Un caso di infezione da Geotrichum capitatum
2005
ThO to Th1 switch of CD4T cell clones specific from the 16-kDa antigen of Mycobacterium tuberculosis after successfull therapy: lack of involvement o…
2005
Cuteneous leishmaniasis (CL) in western Sicily
2005
Epatite virale acuta da HEV a Palermo: descrizione di un caso
2005
Cystic hydatidosis: a rare case of spine localization.
2011
Materno-fetal Toxoplasma gondii infection: critical review of available diagnotic methods
2008
Apoptosi in oociti umani non fecondati dopo ICSI
2004
Procalcitonin levels in plasma in oncohaematologic patients with an without bacterial infections
2004
BACKGROUND: The flogosis markers currently in use show both low sensitivity and specificity, particularly in neoplastic and degenerative diseases. Procalcitonin (PCT) is a pro-peptide of calcitonin produced mainly but not only in the C-cells of the thyroid glands and, as several studies show, PCT levels in plasma increase during infections. Bacterial infections are also the main cause of death in oncological patients. Furthermore, in patients with leukaemia in chemotherapy recovery, infections often induce relapses. The aim of the present study is to detect PCT levels in plasma in oncohaematologic patients with and without infections. METHODS: The study was carried out on 54 patients by a q…
UPREGULATION OF MIR-29A AND GENOMIC DNA HYPERMETHYLATION IN NORMAL KARYOTYPE AML SHOWING DNMT3A MUTATION UPREGOLAZIONE DEL MIR-29A E IPERMETILAZIONE …
2015
DNMT3A, a member of DNA methyltransferases, is mutated in approximately 22% of de novo normal karyotype acute myeloid leukemia (NK-AML) patients leading to adverse overall survival. The highly recurrent mutation in DNMT3A is a “gain of function-like” at codon R882. To indagate about miRNA signature in NK-AML R882-DNMT3A mutated we studied by qRT-PCR the expression of 384 known human miRNA in 9 selected de-novo AML DNMT3A mutated. We compared miRNA expression data with our previous results obtained in 31 AML DNMT3A wild type (WT) and we focused on a strong up-regulation of miR155, miR29a, miR196b and miR25. We consolidated this data in additional 24 new DNMT3A mutated AML and we confirmed th…
Pulmonary tuberculosis in Italian children by age at presentation
2004
La granulisina nella malattia tubercolare: considerazioni su una casistica pediatrica.
2006
Infezione materno-fetale da toxoplasma gondii: analisi critica della diagnosi pre e post-natale
2005
INFEZIONE POLMONARE DA BLASTOSCHIZOMICES CAPITATUS
2005
Geotrichum capitatum, now known as Blastoschizomyces capitatus, can be responsible for several opportunistic infections (systemic infection or localized at lungs, liver, kidney, encephalitis or meningitis) in an immunocompromised host, especially in those patients affected by leukaemia or under immunosuppressive therapies. A 66-year-old woman with polimyosite under steroid and immunosuppressant therapy was hospitalized in ICU for an acute respiratory distress with moderate hypoxaemia and normocapnia. Pulmonary X-ray revealed a bilateral pneumonia. Hypoxaemia became severe 48 hours later and the patient underwent mechanical ventilation and empirical antibiotic therapy. Blood cultures, urine …
Follow-up post natale in nati da madre con infezione certa da Toxoplasma gondii considerazioni sul management prenatale.
2005
The clinical management of perinatal toxoplasmosis involves a gynaecologist during pregnancy and a neonatologist after delivery. Then, in the absence of a uniform approach, early evaluation of infected infants requires a thorough long-term follow-up also in asymptomatic children, who have to be observed for at least one year due to unpredictable sequelae in later life. We retrospectively analyzed pregnancy management of 54 women with certain infection from Toxoplasma gondii (TG) and prospectively enrolled their infants to compare prenatal management with postnatal clinical outcome. All mothers with seroconversion for TG infection were from the Palermo area and were retrospectively analyzed,…
La spondilodiscite oggi: osservazioni su nove casi
2005
Un caso di sinusite da Aspergillus
2006
Infezione actinomicotica: considerazioni su due casi clinici
2006
Apoptosis in human unfertilized oocytes after ICSI
2005
Considerazioni su un caso di schistosomiasi urinaria.
2005
Urinary tract schistosomiasis is a parasitic disease caused by S. haematobium with a wide range of clinical manifestations related to the mucosal and submucosal granulomatous lesions of the bladder. It affects about 80 million people in Africa, Middle-East and India, while in Italy it is rarely seen among immigrants from endemic areas and returning travellers. The authors describe a case occurred in a 26 year old man, recently emigrated from a rural area of Ghana. He had the symptoms of a haemorrhagic cystitis. Cystoscopy and biopsy showed granulomatous lesions of bladder with calcified eggs. Microscopic examination of urine was positive for Schistosoma haematobium eggs. The therapy with Pr…
A novel ELISA system for detecting serum granulysin in tuberculosis patients
2006
Efficacia e tollerabilità di piperacillina/tazobactam in profilassi preoperatoria
2005
Diagnosis of congenital toxoplasmosis: pre e post natal evaluation in a sicilian (Italy) epidemiological area
2006
EMPIEMA PLEURICO MICOTICO: UNA ENTITà CLINICA EMERGENTE
2006
Follow-up diagnostico di bambini con sospetta toxoplasmosi connatale: valutazioni preliminari
2004
Mucormicosi cutanea primitiva: descrizione di un caso clinico
2005
Il significato della proteina C reattiva in cardiochirurgia nella diagnosi delle infezioni post-operatorie
2006
Toxoplasmosi: il western blot nella diagnosi dell'infezione materno-fetale. Dati preliminari
2006
Hormonal, auxological and clinical follow-up in children with connatal HIV infection: personal records
2006
Auxological and endocrinological complications frequently occur in children with connatal HIV infection. These complications seem to be related both to the infection itself and the antiretroviral therapy. Many children consequently show height-weight and pubertal retardation without any evidence of hormonal deficit. We studied 10 children with connatal HIV infection who were enrolled in this analysis and followed up for 7 years in order to evaluate their height-weight growth, pubertal maturation, bone age progression and hormonal pattern [basal Growth hormone (GH) and GH after Clonidine or Insulin stimulation, Insulin-like Growth Factor 1 (IGF-1), Insulin-like Growth Factor Binding Protein …
TBC, LUE e AIDS in immigrati extracomunitari. Considerazioni su tre casi
2006
Piperacillina/tazobactam in terapia empirica
2006
r-lh administration in multiple follicular stimolation for ivf: effects of apoptosis in cumulus cells, oocytes quality and clinical outcome
2005
Endocardite non brucellare
2005
Magnetic resonance and computed tomography findings in childhood central nervous system tuberculosis
2007
Utilizzo delle tre classi di antifungini per la terapia empirica in un reparto di terapia intensiva
2006
[Epidemiology of paediatric tuberculosis today].
2003
Tuberculosis (TB) kills 2 million people each year in the world, of which 250,000 are children. In Italy, paediatric TB is 3.5% of total cases with a steady trend in the last ten years. Childhood tuberculosis remains a disease of great concern because its occurrence always indicates recent transmission and is a pivotal indicator of effectiveness of TB control efforts. The epidemiological study, including DNA fingerprinting, of 71 children affected by TB - 62 pulmonary, 9 meningitis, 2 renal-shows that the source case is frequently a parent or household member. Sensitivity to anti-tubercular drugs was tested for 18/20 isolates obtained from the children and 21/44 isolates obtained from infec…