0000000000157002

AUTHOR

María Suárez-lledó

showing 3 related works from this author

Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

2021

Abstract Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range,…

PNEUMONIAMalevirusesmedicine.medical_treatmentseasonal human coronavirusHematopoietic stem cell transplantationmedicine.disease_causeDISEASElaw.inventionCoronavirus OC43 HumanCLINICAL CHARACTERISTICSlawCoronavirus 229E HumanRisk FactorsImmunology and AllergyChildRespiratory Tract InfectionsNL63 INFECTIONSCoronavirusOUTCOMESRespiratory tract infectionsSYNCYTIAL VIRUSHazard ratioHematopoietic Stem Cell Transplantationvirus diseasesupper and lower respiratory tract diseaseHCoV-NL63HCoV-229Erespiratory systemMiddle AgedIntensive care unitHospitalizationimmunocompromisedsurgical procedures operativeInfectious Diseasesmedicine.anatomical_structureAcademicSubjects/MED00290Child PreschoolCohortFemaleSeasonsCoronavirus InfectionsRare cancers Radboud Institute for Health Sciences [Radboudumc 9]allogeneic hematopoietic stem cell transplantation; community-acquired respiratory virus; HCoV-229E; HCoV-HKU1; HCoV-NL63; HCoV-OC43; immunocompromised; immunodeficiency score index; multiplex PCR assay; seasonal human coronavirus; upper and lower respiratory tract diseaseAdultmedicine.medical_specialtyHCoV-OC43AdolescentDIAGNOSISCHINAHCoV-HKU1BetacoronavirusAll institutes and research themes of the Radboud University Medical Centerstomatognathic systemInternal medicinemedicineMajor ArticleRHINOVIRUSHumansallogeneic hematopoietic stem cell transplantationAgedRetrospective Studiescommunity-acquired respiratory virusbusiness.industryInfantmultiplex PCR assayTransplantationCoronavirus NL63 HumanPARAINFLUENZA VIRUSbusinessimmunodeficiency score indexRespiratory tract
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Assessment of the association between cytomegalovirus DNAemia and subsequent acute graft-versus-host disease in allogeneic peripheral blood stem cell…

2021

The potential role of active CMV infection in promoting acute Graft-versus-Host Disease (aGvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. We further addressed this issue conducting a retrospective, observational, multicenter study of 632 patients subjected to allogeneic peripheral blood HSCT at 20 Spanish centers. Monitoring of CMV DNA load in plasma or whole blood was performed by real-time PCR assays. Cumulative incidence of CMV DNAemia was 48.9% (95% CI, 45%-52.9%), of any grade aGvHD, 45.6; 95% (CI, 41.3%-50.1%), and of grade II-IV aGvHD, 30.7 (95% CI, 24.9%-36.4%). Overall, development of CMV DNAemia at any level resulted in an increa…

medicine.medical_specialtyversus&#8208medicine.medical_treatmentCongenital cytomegalovirus infectionCytomegalovirusGraft vs Host DiseaseDiseaseHematopoietic stem cell transplantationCMV DNAemia030230 surgeryGastroenterologyCMV DNAemia acute graft-versus-host disease allogeneic hematopoietic stem cell transplantation cytomegalovirus (CMV)Cell therapy03 medical and health sciences0302 clinical medicineInternal medicinehemic and lymphatic diseasesMedicineHumansCumulative incidenceallogeneic hematopoietic stem cell transplantationWhole bloodRetrospective StudiesTransplantationhost diseasePeripheral Blood Stem Cell Transplantationbusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesmedicine.diseaseacute graft&#8208TransplantationHaematopoiesisInfectious Diseasessurgical procedures operativecytomegalovirus (CMV)030211 gastroenterology & hepatologybusinessTransplant infectious disease : an official journal of the Transplantation SocietyREFERENCES
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Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transpla…

2020

The net impact of cytomegalovirus (CMV) DNAemia on overall mortality (OM) and nonrelapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. This was a retrospective, multicenter, noninterventional study finally including 749 patients. CMV DNA monitoring was conducted by real-time polymerase chain reaction (PCR) assays. Clinical outcomes of interest were OM and NRM through day 365 after allo-HSCT. The cumulative incidence of CMV DNAemia in this cohort was 52.6%. A total of 306 out of 382 patients with CMV DNAemia received preemptive antiviral therapy (PET). PET use for CMV DNAemia, but not the occurrence of CMV DNAemia, taken …

Oncologymedicine.medical_specialtybone marrowinfection and infectious agents - viralmedicine.medical_treatmentCongenital cytomegalovirus infectionCytomegaloviruscomplicationHematopoietic stem cell transplantation030230 surgerylaw.inventionCell therapy03 medical and health sciences0302 clinical medicinelawInternal medicinehemic and lymphatic diseasesRisk of mortalityImmunology and AllergyMedicineHumansTransplantation HomologousPharmacology (medical)Cumulative incidencePolymerase chain reactionRetrospective StudiesTransplantationbusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesmedicine.diseasepracticeTransplantationinfectious infection and infectious agents - viral: Cytomegalovirus (CMV) [bone marrow/hematopoietic stem cell transplantation clinical research/practice complication]infectiousclinical researchCohortCytomegalovirus InfectionsDNA Viralhematopoietic stem cell transplantationCytomegalovirus (CMV)business
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