0000000000158888
AUTHOR
Giardina Ar
Disfunzione diastolica in pazienti affetti da artrite reumatoide:ruolo della terapia con anti-TNF
Le Spondiloartriti.
Efficacia e sicurezza del trattamento con inibitori del TNF in pazienti affetti da spondilite anchilosante: uno studio osservazionale a 2 anni.
La determinazione degli anticorpi antipeptide, C citrullinato è utile nel discriminare pazienti con artrite reumatoide da quelli con poliartrite associata a tiroidite cronica autoimmune.
Iniezione locale di infliximab nel trattamento della dattilite
DIASTOLIC DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TNF BLOCKING AGENTS
Efficacia e sicurezza di infliximab nelle spondiloartriti indifferenziate: follow-up a 2 anni
Atherosclerosis in female patients with rheumatoid arthritis: a two years of follow up
Disfunzione diastolica in pazienti affetti da artrite reumatoide: ruolo della terapia con anti-TNFα
pentoxifylline inhibits vgamma9/vdelta2 t lymphocyte activation of patients with active behçet's disease
The aim ofthis study is to evaluate the in vitro effect ofpentoxifylline (PTX) on T Vy9No21ymphocyte function in Beheet's disease (DO). We investigated the effect of PTX on Vy9No2 T cell expansion and expression of TNFRII receptor and perforin content before and after PTX addition by means of FACS analysis lymphocyte cultures from patients with active and inactive DO and healthy subjects. The addition of PTX at a concentration of 1 mg/ml determined a significant inhibition of cell expansion, a down regulation of TNF receptor expression and inhibited the PMA-induced degranulation of perforin. Taken together these data indicate that PTX is capable of interfering with Vy9No2 T cell function in…
Profilo citochinico ed espressione di STATS e SOCS nell’intestino di pazienti affetti da spondilite anchilosante
THE LEVEL OF SOLUBLE GRANZYME A IS ELEVATED IN THE PLASMA AND IN THE Vgamma9/Vdelta2 T CELL CULTURE SUPERNATANTS OF PATIENTS WITH ACTIVE BEHCET'S DISEASE
Gramzyme A (GrA) is a serine proteinase with trypsin-like activity that is released extracellularly during the degranulation of cytotoxic cells. Among the cytotoxic cells, gamma/delta T cells participate in the early phases of the immune response and are known to express perforin and granzymes constitutively in agreement with their cytolytic pontential.GrA activity was detected using the synthetic substrate N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester in the plasma and supernatants of peripheral blood mononuclear cell cultured in the presence of Dimethylallyl pyrophosphate to obtain Vgamma9/Vdelta2 T cell expansion.Significantly high levels of GrA were found in the serum and supernat…