0000000000161189

AUTHOR

Marco Thines

showing 6 related works from this author

Genomic basis of drought resistance inFagus sylvatica

2020

In the course of global climate change, central Europe is experiencing more frequent and prolonged periods of drought. These drought events have severe and detrimental impacts on the forest ecosystem. The drought years 2018 and 2019 affected European beeches (Fagus sylvatica L.) in noticeably different ways: even in the same local stand, badly drought damaged trees immediately neighboured apparently healthy trees. This led to the hypothesis that the genotype rather than the environment was responsible for this conspicuous pattern. We used this natural experiment to study the genomic basis of drought resistance in a Pool-GWAS approach. Contrasting the extreme phenotypes, we identified 106 si…

Genetic diversityNatural selectionbiologyFagus sylvaticaEcologyfungiForest ecologyGlobal warmingGenotypefood and beveragesClimate changebiology.organism_classificationBeech
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Back Cover: Promoter Activation in Δ hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Ange…

2019

chemistry.chemical_compoundbiologyBiochemistryChemistryMetaboliteMutantINTCover (algebra)General ChemistryProteobacteriabiology.organism_classificationCatalysisAngewandte Chemie International Edition
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The era of reference genomes in conservation genomics

2022

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics.

QH301 Biology580 Plants (Botany)Genetics -- ResearchEvolutionsbiologibiodiversity conservation; conservation genetics; ERGA; European Reference Genome AtlasConservation genetics; Biodiversity conservation; European Reference Genome Atlas; ERGAAnimal genome mappingudc:630*1GenomeGEERGA[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE][SDE.BE.BIOD]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.biodERGA ; Biodiversity [MeSH] ; Genomics [MeSH] ; Ecology Evolution Behavior and Systematics ; conservation genetics ; Genome [MeSH] ; biodiversity conservation ; European Reference Genome Atlas3rd-DASGenomicsBiodiversityreferenčni genomi[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM][SDE.BE.BEC]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.becChemistry10121 Department of Systematic and Evolutionary BotanygenomikaGE Environmental Sciences:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]biodiverzitetaSettore BIO/18 - GENETICAeducationQH426 GeneticsQH301European Reference Genome AtlasVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470[SDE.BE.EVO]Environmental Sciences/Biodiversity and Ecology/domain_sde.be.evoGeneticsconservation genetics ; biodiversity conservation ; European Reference Genome Atlas ; ERGAgenomi10211 Zurich-Basel Plant Science CenterGenomesGenetikBiologyQH426Ecology Evolution Behavior and SystematicsEvolutionary BiologyBiodiversity conservation; Conservation genetics; European Reference Genome AtlasAmbientaleEcologíaGenética1105 Ecology Evolution Behavior and Systematicsconservation geneticsWildlife conservation570 Life sciences; biologyHuman medicinebiodiversity conservationAnimal genetics[SDE.BE]Environmental Sciences/Biodiversity and EcologyGenètica
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Author response: Genomic basis for drought resistance in European beech forests threatened by climate change

2021

GeographybiologyAgroforestryDrought resistanceThreatened speciesClimate changebiology.organism_classificationBeech
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Rücktitelbild: Promoter Activation in Δ hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (A…

2019

chemistry.chemical_compoundBiochemistryChemistryMetaboliteMutantGeneral MedicineAngewandte Chemie
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Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

2019

Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseud…

bioactivity testingnatural productsMetaboliteMutantPeptide SynthetasesXenorhabdus010402 general chemistry01 natural sciencesCatalysisBiosynthesis | Very Important Paperchemistry.chemical_compoundddc:570RNA chaperoneHumansMetabolomicsGeneResearch ArticlesBiological Productsbiology010405 organic chemistryPseudomonastechnology industry and agricultureGeneral MedicineGeneral Chemistrybiology.organism_classification0104 chemical sciencesBiosynthetic PathwayseasyPACIdchemistryBiochemistryddc:540proteobacteriaPhotorhabdussimplified productionResearch Article
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