0000000000162225

AUTHOR

Pierre Verlhac

Study and optimization of freeze-drying cycles of a model probiotic strain

This work is based on the experimental study of the freeze-drying process to understand the impact of numerous factors on the survival rates of a model probiotic strain of Lactobacillus casei type. With the aim to find out if cell density in the matrix and survival rates are linked, we have studied the location of the cells after freeze drying inside a porous  matrix composed of a lactose basis with a polymer, the polyvinylpyrrolidone (PVP) in various amounts. The best survival rate were obtained at slow freezing rate for a formulation containing 5% (m/V) of lactose and 5% (m/V) of PVP. Keywords: Freeze-Drying; Freezing; Probiotics; L. Casei ATCC 393 

research product

Study and optimization of freeze-drying cycles of model probiotic strain of lactobacillus casei type

International audience

research product

Etude, expérimentation et optimisation des cycles de lyophilisation d'une souche de probiotiques

International audience

research product