SU(3) gauge theory with 12 flavours in a twisted box
We present preliminary result for the step-scaling study of the coupling constant with the Yang-Mills gradient flow, in the twelve-favour SU(3) gauge theory. In this work, the lattice simulation is performed using unimproved staggered fermions and the Wilson plaquette gauge action, from which the gradient flow is also implemented. Imposing twisted boundary condition a'la t'Hooft and Parisi, our calculation is performed at zero fermion mass. The renormalised coupling constant is extracted via the computation of the energy density. In order to examine the reliability of the continuum extrapolation, we investigate this coupling constant using two different lattice discretisations. Our result s…
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
AbstractCutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5′-phosphatase-like protein-1 (INPPL1) and BTB/POZ Domain-Containing Protein 3 (BTBD3). INPPL1 and BTBD3 were downregulated when melanoma cells expressed miR-205, indicating that these genes…