0000000000162768

AUTHOR

Mier Pablo

showing 2 related works from this author

The Protein Structure Context of PolyQ Regions.

2016

Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the region…

Models MolecularProtein Conformation alpha-HelicalProtein Structure ComparisonProtein StructureSaccharomyces cerevisiae ProteinsGlutaminelcsh:MedicineNerve Tissue ProteinsSaccharomyces cerevisiaePlant ScienceResearch and Analysis MethodsBiochemistryPlant Roots570 Life sciencesDatabase and Informatics MethodsProtein Structure DatabasesMacromolecular Structure AnalysisHumansProtein Interaction Domains and MotifsAmino AcidsDatabases ProteinProtein Interactionslcsh:ScienceMolecular BiologyMediator ComplexOrganic CompoundsPlant AnatomyAcidic Amino AcidsOrganic Chemistrylcsh:RChemical CompoundsBiology and Life SciencesProteinsRoot StructureChemistryBiological DatabasesProtein-Protein InteractionsPhysical Scienceslcsh:QStructural ProteinsProtein Structure DeterminationPeptidesResearch Article570 BiowissenschaftenPLoS ONE
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Reading the Evolution of Compartmentalization in the Ribosome Assembly Toolbox: The YRG Protein Family.

2016

Reconstructing the transition from a single compartment bacterium to a highly compartmentalized eukaryotic cell is one of the most studied problems of evolutionary cell biology. However, timing and details of the establishment of compartmentalization are unclear and difficult to assess. Here, we propose the use of molecular markers specific to cellular compartments to set up a framework to advance the understanding of this complex intracellular process. Specifically, we use a protein family related to ribosome biogenesis, YRG (YlqF related GTPases), whose evolution is linked to the establishment of cellular compartments, leveraging the current genomic data. We analyzed orthologous proteins …

ProteomesArchaeal ProteinsMycologyBioenergeticsResearch and Analysis MethodsBiochemistryMicrobiologyMolecular EvolutionGTP PhosphohydrolasesEvolution MolecularFungal ProteinsEukaryotic EvolutionBacterial ProteinsFungal EvolutionAnimalsMolecular Biology TechniquesMolecular BiologyEnergy-Producing OrganellesCell NucleusEvolutionary BiologyMolecular Biology Assays and Analysis TechniquesBacterial EvolutionBiology and Life SciencesProteinsPhylogenetic AnalysisBacteriologyNucleolusCell BiologyOrganismal EvolutionCell CompartmentationMitochondriaProtein TransportMicrobial EvolutionCellular Structures and OrganellesRibosomesResearch ArticlePloS one
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