Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients.

Background. Hypertension and additional non-traditional risk factors can damage the kidney directly and by promoting atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate a large part of the effects of risk factors on the kidney. We hypothesized that in hypertensive patients (HT), oxidative stress, measured as 8-ISO-prostaglandin F2alpha (8-ISO-PGF2alpha), should raise paralleling decreasing renal function and should correlate with estimated glomerular filtration rate (eGFR). Methods. In 626 HT with renal function ranging from stages 1 to 5 and 100 healthy controls, plasma levels of 8-ISO-PGF2alpha, high-sensitivity C-reactive protein (CRP), transfor…

Il controllo pressorio nell’insufficienza renale cronica: valutazione mediante monitoraggio ambulatorio (ABPM).

Markers di fibrosi miocardica e di infiammazione in ipertesi con e senza ipertrofia ventricolare.

Il propeptide carbossi-terminale del collagene tipo I è un predittore indipendente della massa del ventricolo sinistro in pazienti con ipertensione essenziale.

Microalbuminuria and endothelial activation in treated and untreated diabetic and non-diabetic hypertensives

Fetuina-A, infiammazione e massa del ventricolo sinistro in pazienti con chronic kidney disease stage 3-4

Relazione tra la riduzione lieve-moderata della funzione renale e la massa ventricolare sinistra nell’ipertensione arteriosa.

Rapporti tra stato nutrizionale e citokine nell’insufficienza renale cronica

Endotelina-1 e 8-isoprostano predicono il GFR stimato nell’ipertensione arteriosa

Endothelial activation and insulin resistance: Comparison between essential hypertensives and hypertensive patients with Metabolic Syndrome

Oxidant stress inversely relates to renal function in hypertension

C-reactive protein and ICAM-1 are stronger predictors of oxidant stress than blood pressure in established hypertension

Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis

SUMMARY: Aim: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients. Methods: Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded. Results: Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone (P < 0.04) The multiple regression analysis, carried ou…

Attivazione endoteliale in pazienti ipertesi non microalbuminurici

Correlazione di un marker di stress ossidativo con gli indici di disfunzione endoteliale in pazienti con ipertensione essenziale

Endothelial activation and insulin resistance: Comparison beween essential hypertensives and hypertensive patients with metabolic syndrome

Relazione inversa tra stress ossidativo e funzione renale nell’ipertensione arteriosa.

Microalbuminuria and early endothelial activation in essential hypertension

We hypothesized that in essential hypertensive patients (EHs), plasma levels of pro-atherogenic adhesion molecules would be increased and related with urine albumin excretion (UAE). Thus, this study was aimed at evaluating biochemical markers of endothelial activation and their relationship with UAE in a group of patients with uncomplicated EH. In basal condition soluble forms of adhesion molecules intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1, as well as 24-h UAE were assayed. One hundred patients with essential hypertension and no diabetes or ultrasonographic evidence of atherosclerosis were included in the study. Seventy normotensive healthy subjec…

Comparazione dei promotori dell’aterosclerosi in pazienti nefropatici in terapia conservativa e dialitica

Oxidant stress is inversely related to renal function in hypertension.

Markers of endothelial activation and left ventricular hypertrophy in essential hypertension

Fetuin-A plasma concentration and left ventricular mass in essential hypertension

Attivazione endoteliale: confronto tra ipertensione essenziale, sindrome metabolica e diabete mellito associati ad ipertensione

Oxidant stress and endothelial activation in hypertensive patients with and without left ventricular hypertrophy

Plasma endothelin-1 and 8-Iso-ProstaglandinF2alpha levels are related to renal function and predict estimated glomerular filtration rate in hypertensive patients

Fetuin-A and left ventricular hypertrophy in essential hypertension.

Markers of myocardial fibrosis and inflammation in hypertensives with and without left ventricular hypertrophy

Il propeptide carbossi-terminale del collagene di tipo 1 e’ un predittore indipendente della massa del ventricolo sinistro in pazienti con ipertensione essenziale.

Le differenze di genere nei preadolescenti ospedalizzati

Stato nutrizionale e citokine nell’Insufficienza Renale Cronica

Endotelin-1 and 8-isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension

(2006). Oxidant stress and endothelial activation in hypertensive patients with and without left ventricular hypertrophy.

Blood Pressure control by 24-hour Ambulatory Monitoring in Chronic Renal Failure.

Markers di fibrosi miocardica e di infiammazione in ipertesi con e senza ipertrofia ventricolare sinistra

Adiponectin relates inversely to atherosclerotic factors independently of blood pressure in essential hypertension

Nell’ipertensione essenziale, proteina C reattiva ed ICAM-1 sono predittori di stress ossidativo maggiori dei valori pressori.

C-reactive protein and intercellular adhesion molecule-1 are stronger predictors of oxidant stress than blood pressure in established hypertension

Oxidant stress is implicated in the pathogenesis of atherosclerosis in cardiovascular diseases. Our aim was to test oxidative stress, as 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), and its relationship with inflammation markers C-reactive protein (CRP) and tumour necrosis factor-alpha (TNFalpha), and endothelial activation assayed as soluble intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in essential hypertension.In 216 essential hypertensive patients and 55 healthy control individuals, plasma levels of high-sensitivity CRP and TNFalpha, 8-iso-PGF2alpha, ICAM-1 and VCAM-1 were measured in basal conditions. Moreover, basal and 24-h ambulatory blood p…

Association between biomarkers of inflammation and left ventricular hypertrophy in moderate chronic kidney disease.

Aims: Left ventricular hyper- trophy (LVH) is a predictor for cardiovascu- lar mortality, and it is considered to be a surro- gate marker of preclinical cardiovascular dis- ease. This study aimed at evaluating whether fetuin-A plasma levels are decreased in pa- tients with moderate chronic kidney disease (CKD) and their linkage to plasma concentra- tions of hs-C-reactive protein (CRP), cardio- trophyn-1 (CT-1), tumor necrosis factor- (TNF-), propeptide of collagen Type I (PIP) and to LVH. Material and methods: We enrolled 64 moderate CKD and 55 essential hypertensives (EH) with normal renal func- tion as controls. All the patients underwent an echocardiographic examination; plasma sam- ples…

La scuola in ospedale: un’opportunità di attraversamento del rischio per il minore ospedalizzato

12.8 Endotelin-1 and 8-Isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension

La scuola in ospedale: un’opportunità di ‘attraversamento’ del rischio per il bambino ospedalizzato

Aim. The paper reports research on the subject of "Overcoming the illness risk in the School in Hospital service" the aim of which was to monitor this particular service so as to assess whether or not the activities proposed are directed by the model of overcoming inherent risks as defined and reported here. Four research directions were taken to verify the hypothesis whereby the service takes on a supportive-transformative value which enables the hospitalized child to study through his/her illness and is thus able to develop by activating support, protection and diagnosis functions. Methods. The investigation was carried out using the single case methodology which provided for continuous o…

Il controllo pressorio nell’insufficienza renale cronica. Valutazione mediante ABPM