Intravesical gemcitabine in superficial bladder tumours preliminary results of a phase I-II study

INTRODUCTION & OBJECTIVES: Gemcttabme is a pro-drug requmng intracellular phosphorylation by deoxycytidine kinase to be activated. Preliminary experiences. suggesting the activtty and the good tolerability of the drug on superficial transitional cell carcinoma of the bladder (TCCB) when administered by intravesical route, have been recently published. The mm of the present study was to evaluate the ablative efftcacy of weekly intravesical instillations of gemcitabine against paptllary marker lesions left after TUR of superficial TCCB. The scientific background and the ethical acceptability of thts approach have been balidated by the European Organization for Research and Treatment ot Cancer…

L'Urologia in Italia

Infezioni e flogosi delle vie urinarie nella donna

APPROCCIO FARMACOLOGICO NEL PAZIENTE CON MALATTIA NON SUSCETTIBILE DI TERAPE LOCO-REGIONALI AD INTENTO CURATIVO.

Distribution of smoking, water resource and other environmental factors in patients affected by superficial bladder cancer

INTRODUCTION AND OBJECTIVE: The pathogenetic role cancer of sigarette smoking and employment in bladder has been studied, however, that of other environmental factors is not well defined. Case-control studies require high numbers and are expensive. As a preliminary approach to larger case-control studies, the distribution of potential risk factors coming from environmental pollution among patients affected by superficial bladder cancer (TCCB) has been prospectively analized.