0000000000166941
AUTHOR
Christophe Baudouin
T047 Ultrasonic circular cyclo coagulation in patients with primary open-angle glaucoma: a multicenter clinical trial
Purpose To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure in patients with primary open-angle glaucoma (POAG). Methods Prospective multicenter clinical trial. 42 eyes of 42 patients with POAG, intraocular pressure (IOP) > 21 mmHg, an average of 1.65 failed previous surgeries and an average of 3.2 hypotensive medications were insonified with a probe comprising 6 piezoelectric transducers. 18 patients (group 1) were treated with a 4 seconds exposure time for each shot and 24 patients (group 2) with a 6 seconds exposure time. Follow-up visits were performed at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Results IOP was significantly reduced in …
Hyperosmolarity and Benzalkonium Chloride Differently Stimulate Inflammatory Markers in Conjunctiva-Derived Epithelial Cells in vitro
Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva could give new insights into the effect of this preservative on the disease. In a hyperosmolar model on a conjunctiva-derived cell line, and in the presence of BAK, we evaluated key inflammatory markers [CCL2, IL-8, IL-6, macrophage migration inhibitory factor (MIF) and intercellular adhesion molecule (ICAM)-1] as well as the osmoprotectant element nuclear factor of activated T…
Multicenter clinical trial of ultrasonic circular cyclo coagulation in patients with open-angle glaucoma: One year results
International audience; Purpose: To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure with one year of follow-up. Methods: Prospective non comparative interventional clinical study performed in 9 French glaucoma centers. Fifty-two eyes of 52 patients with open-angle glaucoma, intraocular pressure (IOP) > 21 mmHg, an average of 1.7 failed previous surgeries and an average of 3.7 hypotensive medications were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated, 24 patients (group 1) were treated with a 4 seconds exposure time for each shot and 28 patients (group 2) with a 6 seconds exposure time. C…
Patient/physician "Bond" in the management of glaucoma
Patient/physician "Bond" in the management of glaucoma. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Risk factors associated with primary open-angle glaucoma and ocular hypertension: French epidemiological case control study
International audience
Improvement of dry eye symptoms with polyunsaturated fatty acids
International audience; Purpose: Polyunsaturated fatty acids (PUFA) are involved in inflammatory pathways via prostaglandins. Conjunctival inflammation is a hallmark of all dry eye syndromes. We investigated the role of dietary n–6 and n–3 fatty acids in patients suffering from ocular dryness with peculiar attention to inflammatory markers. Methods: 70 patients presenting with mild to moderate dry eye syndromes were randomly assigned to Nutrilarm® or placebo pills, thrice a day for 6 months. Schirmer test, BUT, fluorescein and lissamin green stainings were performed at inclusion and after 1, 3 and 6 months. Impression cytology to evaluate MHCII antigens was harvested at D0, Month 3 and 6. T…
Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca
Abstract Purpose To investigate by flow cytometry and impression cytology (IC) specimens the inflammatory status of the conjunctival epithelium and goblet cell density in two series of patients with rosacea and dry eye syndrome compared with a population of healthy subjects. Design Nonrandomized, prospective, comparative case series. Participants Twenty-six eyes of 13 patients with rosacea, 26 eyes of 13 patients with dry eye syndrome, and 24 eyes of 12 control subjects were included in this study. Methods IC specimens were collected after clinical examination of the ocular surface and analyzed by flow cytometry, using antibodies directed to human lymphocyte antigen-DR (HLA-DR), intercellul…