0000000000170789
AUTHOR
Daniel Nagel
Transatlantic Trade Wars: The United States and the European Union in Endless Confrontation
Considering two highly interlinked economies of such tremendous size as the United States (US) respectively the European Union (EU), it does not come as a surprise that these circumstances inevitably provide fertile soil for transatlantic trade disputes to thrive. In spite of their decisive contribution to the postwar trade liberalization process, the two giants never quit being protectionist in certain particular domains considered sensitive for one part or the other. Sensitive domains are those in which nations fear competition from abroad, in apprehension of being disruptive to their own economy. Usually sectors that are incapable of withstanding foreign competition, most often agricultu…
FLRT structure: Balancing repulsion and cell adhesion in cortical and vascular development
Summary FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We apply this knowledge to elucidate FLRT functions during cortical development. We show that FLRTs regulate both the radial migration of pyramidal neurons, as well as their tangential spread. Mechanistically, radial migration is controlled by repulsive FLRT2-Unc5D interactions, wh…